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EC number: 203-558-5 | CAS number: 108-18-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: Health Council of the Netherlands (2003)
- Overall assessment factor (AF):
- 27
- Modified dose descriptor starting point:
- LOAEC
- AF for dose response relationship:
- 3
- AF for other interspecies differences:
- 3
- AF for intraspecies differences:
- 3
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 18 mg/m³
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- other: Health Council of the Netherlands
- Overall assessment factor (AF):
- 27
- Dose descriptor:
- LOAEC
- AF for dose response relationship:
- 3
- AF for other interspecies differences:
- 3
- AF for intraspecies differences:
- 3
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 18 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 125
- Dose descriptor starting point:
- LOAEC
- AF for dose response relationship:
- 10
- Justification:
- Default AF considering that Diisopropylamine induced histological changes in the nasal passages of mice at concentrations of 257 mg/m3 and higher after a 4-day exposure (6 hours per day, 5 days per week) (Zissu, 1995)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Not needed
- AF for other interspecies differences:
- 2.5
- Justification:
- Default AF
- AF for intraspecies differences:
- 5
- Justification:
- Default AF
- AF for the quality of the whole database:
- 1
- Justification:
- Not needed
- AF for remaining uncertainties:
- 1
- Justification:
- Not needed
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 150 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- Not needed
- AF for differences in duration of exposure:
- 6
- Justification:
- Default AF
- AF for interspecies differences (allometric scaling):
- 2.5
- Justification:
- Default AF
- AF for other interspecies differences:
- 4
- Justification:
- Default AF
- AF for intraspecies differences:
- 5
- Justification:
- Default AF
- AF for the quality of the whole database:
- 1
- Justification:
- Not needed
- AF for remaining uncertainties:
- 1
- Justification:
- Not needed
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.22 mg/cm²
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 10
- Dose descriptor:
- other: NOAEL
- AF for dose response relationship:
- 1
- AF for differences in duration of exposure:
- 2
- Justification:
- There was no evidence of skin irritation in rats treated with doses up to 150 mg/kg bw/day Diisopropylamine for 1 week or 1 month (Naylor, 1987), indicating that the irritating effect is more dose-related than duration-related. Therefore, an AF of 2 will be used to extrapolate for a subacute to a chronic exposure duration.
- AF for interspecies differences (allometric scaling):
- 1
- AF for other interspecies differences:
- 1
- AF for intraspecies differences:
- 5
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
Occupational exposure limits (8 -h time weighted average) of 5 ppm have been adopted in different European countries (Austria, Belgium, Germany, Great Britain, France, Sweden and Denmark) and in USA (ACGIH, OSHA, NIOSH).
Substance |
Diisopropylamine |
CAS No. |
108-18-9 |
Limit value - Eight hours |
Limit value - Short term |
|
ppm |
mg/m³ |
ppm |
mg/m³ |
Austria |
5 |
20 |
10 |
40 |
Belgium |
5 |
21 |
|
|
Canada - Québec |
5 |
21 |
|
|
Denmark |
5 |
20 |
10 |
40 |
European Union |
|
|
|
|
France |
5 |
20 |
|
|
Germany (AGS) |
|
|
|
|
Germany (DFG) |
|
|
|
|
Hungary |
|
|
|
|
Italy |
|
|
|
|
Japan |
|
|
|
|
Poland |
|
|
|
|
Spain |
5 |
21 |
|
|
Sweden |
5 |
20 |
10 |
40 |
Switzerland |
5 |
20 |
|
|
The Netherlands |
|
|
|
|
USA - NIOSH |
5 |
20 |
|
|
USA - OSHA |
5 |
20 |
|
|
United Kingdom |
5 |
21 |
|
|
|
Remarks |
Spain |
skin |
However, a recent review was performed by the Committee on Updating of Occupational Exposure Limits, a committee of the Health Council of the Netherlands (Health-based Reassessment of Administrative Occupational Exposure Limits, Diisopropylamine (CAS No: 108-18-9). No. 2000/15OSH/080, The Hague, 22 October 2003). The committee takes the LOAEL of 100 mg/m3for both systemic toxicity and local irritation found in the 1-month inhalation study in rats (Val Roloff, 1987) as a starting point in deriving a health-based recommended occupational exposure limit (HBROEL). For the extrapolation to a HBROEL, an overall assessment factor of 27 was used. This factor covers the following aspects: the absence of a NOAEL and intra- and interspecies variations. Thus, applying this factor and the preferred value approach, a health-based occupational exposure limit of 5 mg/m3(1.2 ppm) was recommended for diisopropylamine. The committee recommended a health-based occupational exposure limit for diisopropylamine of 5 mg/m3(1.2 ppm), as an 8-hour time-weighted average (TWA).
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.6 mg/m³
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.6 mg/m³
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 83 µg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 50 mg/kg bw/day
- AF for dose response relationship:
- 1
- AF for differences in duration of exposure:
- 6
- AF for interspecies differences (allometric scaling):
- 4
- AF for other interspecies differences:
- 2.5
- AF for intraspecies differences:
- 10
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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