Registration Dossier
Registration Dossier
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EC number: 205-517-7 | CAS number: 141-98-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- OCT 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7860 (Water Solubility Generator Column Method)
- GLP compliance:
- no
- Type of method:
- flask method
- Key result
- Water solubility:
- ca. 2.96 g/L
- Temp.:
- 25 °C
- pH:
- ca. 4
- Key result
- Water solubility:
- ca. 2.65 g/L
- Temp.:
- 25 °C
- pH:
- ca. 7
- Key result
- Water solubility:
- ca. 2.59 g/L
- Temp.:
- 25 °C
- pH:
- ca. 9
- Conclusions:
- Interpretation of results: soluble (1000-10000 mg/L)
The water solubility at 25ºC and pH 4: 2.96 g/L, pH 7: 2.65 g/L, pH 9: 2.59 g/L - Executive summary:
The water solubility test was done according to OECD 105. Flask method was used. The water solubility at 25ºC and pH 4 is 2.96 g/L, at pH 7 is 2.65 g/L and at pH 9 is 2.59 g/L.
Reference
Preliminary test
After the addition of 100 mL of buffer the test item was completely dissolved. Hence the preliminary test displayed solubility of the test item between 1 and 10 g/L. This is the case for all three buffer solutions.
When the test item is added aqueous solution, excess material is found at the surface of the aqueous solution. This makes it difficult to execute the flask method according to the guidelines, since the risk of contamination when taking an aliquot of the aqueous solution for analysis is too high. However, since the solubility is relatively high (1 to 10 g/L), the water solubility is determined using an extended preliminary test. This was done for all threee buffer solutions.
Description of key information
The water solubility test was done according to OECD 105. Flask method was used. The water solubility at 25 ºC and pH 4 is 2.96 g/L, at pH 7 is 2.65 g/L and at pH 9 is 2.59 g/L.
Key value for chemical safety assessment
- Water solubility:
- 2.65 g/L
- at the temperature of:
- 25 °C
Additional information
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