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EC number: 256-170-3 | CAS number: 44914-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Toxicity of 2-methylbutyl acrylate to aquatic organisms was assessed in single tests to each taxonomic level. Results of these assays were considered reliable without restriction. The 2-MBA data are suitable for Risk Assessment, Classification & Labelling, and PBT Analysis. Supporting aquatic toxicity studies using n-butyl acrylate give results in a similar range to 2-MBA. n-Butyl acrylate is of similar molecular weight to 2-MBA (MW 128.2 and 142.2 for n-BA and 2-MBA, respectively) and lipophilicity (log Kow 2.38 and 2.90 for n-BA and 2-MBA, respectively). The toxicity of acrylates with log Kow < 4(1)is due to electrophilic interactions (Michael addition) to cellular nucleophiles(2,3), causing glutathione depletion(2)and protein inactivation(3). Detoxification is by ester hydrolysis followed by downstream conversion and entry of acrylic acid to the citric acid cycle(4).While the biodegradation screening study result for isooctyl acrylate was used to support ready biodegradability of 2-MBA, read-across of aquatic toxicity data from isooctyl acrylate (IOA) to 2-MBA is generally not supported due to IOA’s substantially higher molecular weight (MW 184.3) and lipophilicity (log Kow 4.5-4.7). Substantially greater toxicity of IOA than 2-MBA or n-BA is generally found. However, all three acrylates are readily biodegradable, which limits their potential for chronic toxicity.
References:
1. USEPA Office of Pollution Prevention and Toxics. 2002. TSCA New Chemical Program (NCP) Chemical Categories.
2. A. P. Freidig, H. J. M. Verhaar, J. L. M. Hermens. 1999. Comparing the Potency of Chemicals with Multiple Modes of Action in Aquatic Toxicology: Acute Toxicity Due to Narcosis versus Reactive Toxicity of Acrylic Compounds. Env. Sci. Technol. 33 (17): 3038–3043.
3. K. Chan & P. J. O’Brien. 2008. Structure–activity relationships for hepatocyte toxicity and electrophilic reactivity of a,b-unsaturated esters, acrylates and methacrylates. J. Appl. Toxicol. 28 (8): 1004–1015.
4. H. Greim, J. Ahlers, R. Bias, B. Broecker, H. Hollander, H.-P. Gelbke, S. Jacobi, H.-J. Klimisch, I. Mangelsdorf, W. Mayr, N. Schön, G. Stropp, P. Stahnecker, R. Vogel, C. Weber, K. Ziegler-Skylakakis, E. Bayer. 1995. Assessment of structurally related chemicals: Toxicity and ecotoxicity of acrylic acid and acrylic acid alkyl esters (acrylates), methacrylic acid and methacrylic acid alkyl esters (methacrylates). Chemosphere 31 (2): 2637–2659.
Data matrix – Analog approach (all data experimental except as noted) |
||
Target substance |
Source substance |
|
CHEMICALNAME |
2-methylbutyl acrylate |
n-butyl acrylate |
CAS# |
44914-03-6 |
141-32-2 |
Molecular formula |
C8H14O2 |
C7H12O2 |
Molecular Weight |
142.2 |
128.2 |
PHYSICO-CHEMICAL DATA |
||
Melting Point |
≤ -75 °C |
Not available |
Boiling Point |
161.7 °C at 1013hPa |
147 °C at 1013hPa |
Density |
0.8886 g/cm3 at 25 °C |
0.9 g/cm3 at 20.0 °C |
Vapour Pressure |
1.7 hPa at 20°C |
5 hPa at 22.2°C |
Partition Coefficient (log Kow) |
2.9 |
2.38 (at 25°C) |
Water Solubility |
316 mg/L at 23 °C |
Not available |
ENVIRONMENTAL FATE and PATHWAYS |
||
Photodegradation |
DT50 1.04 d (QSAR: AOPWIN v1.92) |
Not determined |
Stability in Water |
Adaptation, readily biodegradable |
DT50, 1100 day at pH 7, 25 °C (40CFR796.3500) |
Aerobic Biodegradation |
60% after 11 days (OECD 301D) |
80 - 90% after 28 days (OECD 310) |
Bioconcentration |
Not bioaccumulative |
Not bioaccumulative |
Transport and Distribution |
Koc 263 – 302 (Calculated by TGD method) |
Koc 40-148 (EPA OTS 796.2750) |
Henry's Law constant |
96 Pa*m3/mol at 23.1 °C |
Not determined |
ENVIRONMENTAL TOXICITY |
||
Acute Toxicity to Fish (P. promelasunless noted) |
96-hour LC50 1.09 mg/L (OECD 203) |
96-hour LC50 5.2 mg/L (S. gairdneri, EPA OTS 797.1400); 96-hour LC50 2.1 mg/L (C. variegatus, OECD203) |
Chronic Toxicity to Fish |
Adapted (readily biodegradable) |
Not determined |
Acute Toxicity to Aquatic Invertebrates (D. magna) |
48-hour EC50 (mobility) 5.65 mg/L (OECD 202) |
48-hour EC50 (mobility) 8.2 mg/L (EPA OTS 797.1300) |
Long-Term Toxicity to Aquatic Invertebrates (D. magna) |
21-day NOEC (growth) 0.249 mg/L (OECD 211) |
21-day NOEC (reprod) 0.136 mg/L (OECD 211) |
Toxicity to Algae and Aquatic Plants (P. subcapitata) |
72-hour ErC50 1.15 mg/L (OECD 201) |
96-hour EbC50 2.65 mg/L (OECD 201) |
Toxicity to Microorganisms (activated sludge respiration) |
3-hour EC50 >1000 mg/L (OECD 209) |
3d EC50 >150 mg/L (ASTM STP 528) |
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