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EC number: 239-784-6 | CAS number: 15687-27-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented non-guideline study; with acceptable restrictions (e.g. no details on the test substance, GLP compliance not verified).
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute and chronic effects of ibuprofen in the mollusc Planorbis carinatus (Gastropoda: Planorbidae)
- Author:
- Pounds, N., Maclean, S., Webley, M., Pascoe, D., Hutchinson, T.
- Year:
- 2 008
- Bibliographic source:
- Ecotoxicology and Environmental Safety; vol. 70, pp. 47 - 52
Materials and methods
- Principles of method if other than guideline:
- The long-term toxicity of ibuprofen to molluscs (Planorbis carinatus; gastropoda) was investigated by an 21-d exposure treatment of juvenile snails to test substance concentrations between 0.32 and 10 mg/L (nominal). Based on endpoint parameters like mortality, reproduction (hatching success) and growth (wet weight) 21-d NOEC and LOEC values could be determined.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ibuprofen
- EC Number:
- 239-784-6
- EC Name:
- Ibuprofen
- Cas Number:
- 15687-27-1
- Molecular formula:
- C13H18O2
- IUPAC Name:
- 2-(4-isobutylphenyl)propanoic acid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
Test organisms
- Test organisms (species):
- other aquatic mollusc: Planorbis carinatus (gastropoda; planorbidae)
- Details on test organisms:
- TEST ORGANISM
- Common name: Ramshorn snail
- Source: Adult organisms were collected from aquatic stock ponds at Seyngenta's Jealott's Hill Reasearch Station, Bracknell, UK
- Housing: cultured in 1L glass bowls, in municipal tap water (AstraZeneca, Brixham)
- Housing temperature: 20 ±1°C
- Feeding during test: yes; ad libitum
- Food type: fresh lettuce and fish flake
- Amount: ad libitum
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
Test conditions
- Test temperature:
- 20 ± 1°C
- pH:
- 6.76 - 7.85
- Dissolved oxygen:
- 6.2 - 9.3 mg/L
- Nominal and measured concentrations:
- nominal test concentrations: 0 (control), 0.32, 1.0, 3.2 and 10.0 mg/L
measured test concentrations: 0 (control), 0.41, 1.02, 2.43 and 5.36 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass tank (max. volume 9.5 L; 305 x 205 x 210 mm)
- No. of organisms per vessel: 20
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 3
- Renewal rate of test solution (frequency/flow rate): seven volume changes per day (flow through)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- mortality
- reproduction (hatching success)
- growth (wet weight) - Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 5.36 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 5.36 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.43 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks:
- (hatching success)
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 5.36 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks:
- (hatching success)
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.02 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Remarks:
- (wet weight)
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 2.43 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Remarks:
- (wet weight)
Any other information on results incl. tables
Summary of survival, growth and reproduction in P. carinatus after 21 d exposure:
Control (Dilution water)
Endpoint |
Measured (and nominal) test concentration [mg/L] |
||
Day 7 |
Day 14 |
Day 21 |
|
Survival [%] |
100 |
98.3 |
98.3 |
Wet weight [g] |
0.123 |
0.128 |
0.128 |
Hatching success [%] |
69.7 |
Control (Solvent)
Endpoint |
Measured (and nominal) test concentration [mg/L] |
||
Day 7 |
Day 14 |
Day 21 |
|
Survival [%] |
100 |
100 |
100 |
Wet weight [g] |
0.125 |
0.157 |
0.113 |
Hatching success [%] |
84.1 |
Test concentration 0.41 mg/L (measured)
Endpoint |
Measured (and nominal) test concentration [mg/L] |
||
Day 7 |
Day 14 |
Day 21 |
|
Survival [%] |
100 |
100 |
98.3 |
Wet weight [g] |
0.124 |
0.160 |
0.113 |
Hatching success [%] |
No eggs laid |
Test concentration 1.02 mg/L (measured)
Endpoint |
Measured (and nominal) test concentration [mg/L] |
||
Day 7 |
Day 14 |
Day 21 |
|
Survival [%] |
100 |
100 |
100 |
Wet weight [g] |
0.133 |
0.145 |
0.105 |
Hatching success [%] |
50.5 |
Test concentration 2.43 mg/L (measured)
Endpoint |
Measured (and nominal) test concentration [mg/L] |
||
Day 7 |
Day 14 |
Day 21 |
|
Survival [%] |
100 |
98.3 |
98.3 |
Wet weight [g] |
0.107 |
0.129 |
0.097 |
Hatching success [%] |
72.9 |
Test concentration 5.36 mg/L (measured)
Endpoint |
Measured (and nominal) test concentration [mg/L] |
||
Day 7 |
Day 14 |
Day 21 |
|
Survival [%] |
100 |
95 |
91.7 |
Wet weight [g] |
0.104 |
0.105 |
0.096 |
Hatching success [%] |
0 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.