5'-chloro-2'-methoxyacetoacetanilide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1989-10-11 to 1989-11-06

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study was performed according to EG Guideline B.1. 84/449/EWG, OECD 401 and GLP.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1989

Report date:

1989

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.1 (Acute Toxicity (Oral))

Deviations:

no

GLP compliance:

yes

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

5'-chloro-2'-methoxyacetoacetanilide

EC Number:

258-189-2

EC Name:

5'-chloro-2'-methoxyacetoacetanilide

Cas Number:

52793-11-0

Molecular formula:

C11H12ClNO3

IUPAC Name:

N-[5-chloro-2-(methoxyacetyl)phenyl]acetamide

Constituent 2

Reference substance name:

Acetessig-4-chlor-o-anisidid

IUPAC Name:

Acetessig-4-chlor-o-anisidid

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

Appearance: white solid powder
Purity: > 99%
Lot: T021
Storage: in the dark at 20°C, under a hood

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: Starch slime 2%

Doses:

3 dose concentrations:
Male: 1600 mg/kg, 2000 mg/kg, 2500 mg/kg bw
Female: 2000 mg/kg bw

4'000 mg/kg
5'000 mg/kg
6'300 mg/kg
8'000 mg/kg

No. of animals per sex per dose:

5 animals per dose
Male and female rats used.

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Any other information on results incl. tables

Results:

Dose Level in mg/kg bw	Male animals mortality		Female animals mortality
	absolute	relative (%)	absolute	relative (%)
1600	0 / 5	0	-	-
2000	2 / 5	40	0 / 5	0
2500	2 / 5	40	-	-

 

 

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LD50 to male and female rats of the test item was determined to be greather than 2000 mg/kg body weight.

Executive summary:

The study was performed according to EG Guideline B.1. 84/449/EWG, OECD 401 and GLP.

The LD50 to male and female rats of the test item was determined to be greather than 2000 mg/kg body weight.