Registration Dossier
Registration Dossier
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EC number: 238-969-9 | CAS number: 14901-07-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: Conclusion of WoE summary report
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- There are various supporting studies available that depict the LD50 value to be well over the range (2000 mg/Kg body weight). Some values have also be taken from structurally similar substances which too prove that 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one shall not exhibit acute dermal toxicity.
Data source
Reference
- Reference Type:
- other: conclusion of WoE Study
- Title:
- Weight of evidence for oral acute toxicity of 14901-07-6
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- Sustainability Support Services (Europe) AB Report
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Weight of evidence
- GLP compliance:
- no
- Test type:
- other: acute toxicity test
Test material
- Reference substance name:
- 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one
- EC Number:
- 238-969-9
- EC Name:
- 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one
- Cas Number:
- 14901-07-6
- Molecular formula:
- C13H20O
- IUPAC Name:
- 4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one
- Test material form:
- other: oily liquid
- Details on test material:
- -Name of test material (as cited in study report): 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one
- Substance type: Organic
- Physical state: liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- No. of animals per sex per dose:
- 10 mice
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 - 7 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the endpoint varies between >2000 mg/L to 7000 mg/L it can be concluded that the substance 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one (b-ionone)is not toxic by dermal route.
- Executive summary:
Five studies reviewed for acute dermal toxicity endpoints on mouse from reliable sources having Klimish rating 4
The summary if the results are presented below
Sr. No
Endpoint name
Value
Units
Remarks
1
LD 50
>2000
mg/kg
-
2
LD 50
3290
mg/kg
-
3
LD 50
5331
mg/kg
-
4
LD 50
6657
mg/kg
-
5
LD 50
7000
mg/kg
Based on the above the endpoint varies between >2000 mg/L to 7000 mg/L therefore it can be concluded that the substance 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one (b-ionone)is not toxic by dermal route.
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