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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
Please see read-across justification document in Chapter 13
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Key result
Reading:
2nd reading
Hours after challenge:
48
Group:
test chemical
Dose level:
100 %
No. with + reactions:
0
Total no. in group:
20
Remarks on result:
no indication of skin sensitisation
Reading:
2nd reading
Hours after challenge:
48
Group:
negative control
Dose level:
100
No. with + reactions:
0
Total no. in group:
10
Remarks on result:
no indication of skin sensitisation
Reading:
2nd reading
Hours after challenge:
48
Group:
positive control
Dose level:
3 %
No. with + reactions:
10
Total no. in group:
10
Remarks on result:
positive indication of skin sensitisation
Interpretation of results:
GHS criteria not met
Conclusions:
Based on the results of the studies with 3 similar substances 2-dodecylhexadecan-1-ol is not sensitising.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Data on skin sensitising are available for 2-butyloctan-1-ol (C12), 2 -octyldodecan-1-ol (C20) and a mixture of the two C20 isomers 2-octyldodecan-1-ol and 2 -hexyltetradecan-1-ol. All substances showed no skin sensitising effects in the guinea pig. As all substances of the category of Guerbet alcohols have the same structure with no additional functional groups only differing in carbon chain lengths the whole category is regarded as not sensitising.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Available data are conclusive but not sufficient for classfication of 2 -dodecylhexadecan-1-ol with regard to skin sensitisation.

There are data lacking for the classification of 2 -dodecylhexadecan-1-ol with regard to respiratory sensitisation.