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EC number: 266-005-7 | CAS number: 65996-72-7 The dust generated during the charging, operation, and tapping of a steelmaking furnace and from steel conditioning, including that which is recovered through the use of pollution abatement equipment. Composed primarily of iron oxides. May contain varying amounts of other metallic oxides and trace compounds.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Evaluation of toxicokinetics of the substance Dust, steelmaking was performed. Evaluation of toxicokinetics of the substance is required according to the 8.8.1 of Annex VII to the Directive (EC) No. 1907/2006 (REACH). The data used for the evaluation originated from three sources:
- Experimental data of toxicological tests (unpublished)
- Literature data obtained from internet
- Data from toxicological databases - free and commercial
Key value for chemical safety assessment
Additional information
The substance, Dust, steelmaking, was applied to laboratory animals (rat, mouse, and rabbit) during studies with different way of entry into organism (e.g. stomach, respiratory tract - nose, skin and eye).
Only mild systemic were described after single oral application of the dose level 2000 mg/kg of the substance to rats. Observed changes faded away till 24 hours after application of the test substance.
Common clinical abnormalities were noted after 4-hour nose exposure of the substance at the concentration of 5.15 mg/l.
After single application on skin of rabbit, no irritant or corrosive effects were observed.
Examination of eye after single application of substance to the conjunctival sac demonstrated, that Dust, steelmaking, is irritating for eye of rabbit; the changes observed were reversible. No corrosive effects were observed on eyes of rabbit and no clinical signs of systemic intoxication were detected.
The substance, Dust, steelmaking, may cause skin sensitisation by skin contact (in accordance with result a mouse LLNA test). No clinical signs of systemic intoxication were detected in study of sensitization.
The oral administration of the test substance to rats by gavage for a period of 28 consecutive days at dose levels 120, 300 and 750 mg/kg/day did not cause mortality.
The haematology examination showed an effect on total leucocyte count (statistically significant increase) in males of middle dose level with irreversible effect.
Only one statistically significant effect, which was manifested in results of biochemical examination was the increase of calcium and phosphorus ions concentrations in peripheral blood. Increase of weight of liver (with dependence on dose level in males) can be indications of affection of liver metabolism but during histopathological investigation no changes of hepatocytes morphology were observed.
In Reproduction/Developmental Toxicity Screening Test the following dose levels: 100, 300 and 900 mg/kg/day were administered. The application of the test substance did not cause the death of any female or male. The test substance affected reproductive system of parental males. The test substance had probably injurious effect on sperm quality of treated males.
In Prenatal Developmental Toxicity Study the following dose levels: 1000, 400 and 160 mg/kg/day were administered. The application of the test substance did not cause the death of pregnant females. No effect of the test substance on maternal animals was observed. Test substance application did not induce external and/or visceral malformations of foetuses (permanent structural change that may adversely affect survival).Delayed development of foetuses - delayed ossification of cranial, sternum skeleton and sacral vertebrae, was detected at all dose levels. These findings related with decreased individual body weights of some foetuses. The test substance treatment evoked occurrence of variations – wavy ribs in all treated groups, so it indicates teratogenic properties of the test substance (it did cause morphologic changes of skeleton) on early prenatal development of organism in uterus.
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