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EC number: 418-480-9 | CAS number: 138526-69-9 1-BROM-3,4,5-TRIFLUORBENZOL; 1-BROMO-3,4,5-TRIFLUOROBENZENE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995-05-01 to 1995-05-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Safepharm
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge: A mixed population of activated sewage sludge micro-organisms was obtained from the secondary treatment stage of the Severn Trent Water Plc sewage treatment plant at Belper, Derbyshire.
- Preparation of inoculum: The sample of activated sewage sludge was allowed to settle for approximately 1 hour, the supernatant removed and maintained on continuous aeration at a temperature of 21 °C prior to use. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 4 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: According to OECD Guideline
- Test temperature: 21 °C
- Inoculum concentration: 1 drop of inoculum/L
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 250-300 mL Biological Oxygen Demand (BOD) bottles (darkened glass) with ground glass stoppers.
- Number of culture flasks/concentration: 2
- Measuring equipment: Dissolved oxygen concentrations were determined by means of a Yellow Springs BOD Probe (Model 54) and oxygen meter.
SAMPLING
- Sampling frequency: Dissolved oxygen concentrations for each test media were determined on days 0, 3, 6, 9, 12, 15, 21 and 28
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Toxicity control: yes - Reference substance:
- benzoic acid, sodium salt
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 13
- Sampling time:
- 28 d
- Details on results:
- Points of degradation plot (test substance):
3 % degradation after 3 d
2 % degradation after 6 d
2 % degradation after 9 d
10 % degradation after 12 d
11 % degradation after 15 d
13 % degradation after 21 d
13 % degradation after 28 d
Toxicity control:
33% degradation after 28 days, thereby confirming that the test material was not toxic to the sewage treatment microorganisms. - Results with reference substance:
- Points of degradation plot (reference substance):
29 % degradation after 3 d
52 % degradation after 6 d
71 % degradation after 9 d
74 % degradation after 12 d
75 % degradation after 15 d
77 % degradation after 21 d
77 % degradation after 28 d - Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Degradation of the test item was examined in a test according to OECD 301D (Closed Bottle Test). After 28 days, 13% degradation were observed.
- Executive summary:
The test item was investigated for its ready biodegradability in a Closed Bottle Test over a period of 28 days according to OECD TG 301D.The test material was exposed to sewage sludge micro-organisms at a concentration of 4 mg/L with culture medium in sealed culture vessels in the dark at 21°C for 28 days. The degradation of the test material was assessed by the determination of the amount of oxygen consumed. Control solutions with inoculum and the standard material, sodium benzoate, together with a toxicity control were used for validation purposes. The test material attained 13% degradation after 28 days and therefore cannot be considered to be readily biodegradable.
Reference
Description of key information
Degradation of the test item was examined in a test according to OECD 301D (Closed Bottle Test). After 28 days, 13% degradation were observed (reference 5.2.1-1).
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
The test item was investigated for its ready biodegradability in a Closed Bottle Test over a period of 28 days according to OECD TG 301D.The test material was exposed to sewage sludge micro-organisms at a concentration of 4 mg/L with culture medium in sealed culture vessels in the dark at 21°C for 28 days. The degradation of the test material was assessed by the determination of the amount of oxygen consumed. Control solutions with inoculum and the standard material, sodium benzoate, together with a toxicity control were used for validation purposes. The test material attained 13% degradation after 28 days and therefore cannot be considered to be readily biodegradable (reference 5.2.1-1).
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