Registration Dossier
Registration Dossier
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EC number: 201-199-9 | CAS number: 79-36-7
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No GLP and no guideline was followed. Only the liver was examined for effects.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
- Principles of method if other than guideline:
- The Wist 30 young rats (from Biobaza IISP, Cluj-Napoca, Romania), of both sexes, weighing 70-150 g, divided into 3 groupswere used. Control group, consisting 10 rats (5 males and 5 females) and tested groups consisting 10 rats (5 males and 5 females). One tested group was treated with 1% DL50 concentration dichloroacetyl chloride and the other with 5% DL50 concentration dichloroacetyl chloride. active. Dose was administrated at the beginning of the experiment and then twice a week. The conditions of care, feeding and administration were the same in' all the groups.The animals were monitored to fully consume the mixture received. On the 28th day of experiment animals were killed after deep anesthesia with ether and then, after laparotomy, the liver was harvested from which we sampled fragments for histological processing.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dichloroacetyl chloride
- EC Number:
- 201-199-9
- EC Name:
- Dichloroacetyl chloride
- Cas Number:
- 79-36-7
- Molecular formula:
- C2HCl3O
- IUPAC Name:
- 2,2-dichloroacetyl chloride
- Details on test material:
- - Name of test material (as cited in study report): dichloroacetyl chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 70-150g
Administration / exposure
- Route of administration:
- other: oral with milk
- Vehicle:
- other: sunflower oil
- Duration of treatment / exposure:
- 4 weeks
- Frequency of treatment:
- daily
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
1 % of LD50/d
Basis:
no data
- Remarks:
- Doses / Concentrations:
5%of LD50/d
Basis:
no data
- No. of animals per sex per dose:
- 5 per sex
- Control animals:
- yes
Results and discussion
Results of examinations
- Details on results:
- In kidney and liver, no compound-related histopathological changes were evident
Kidney as well as liver: no substance-related histopathological effects were observed
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Dichloroacetyl chloride does not show any toxic effect on the liver as far as the above concentrations and methodology are concerned.
- Executive summary:
The Wist 30 young rats (from Biobaza IISP, Cluj-Napoca, Romania), of both sexes, weighing 70-150 g, divided into 3 groupswere used. Control group, consisting 10 rats (5 males and 5 females) and tested groups consisting 10 rats (5 males and 5 females). One tested group was treated with 1% DL50 concentration dichloroacetyl chloride and the other with 5% DL50 concentration dichloroacetyl chloride (dose repeated twice per week).
In conclusion, dichloroacetyl chloride does not show any toxic effect on the liver as far as the above concentrations and methodology are concerned.
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