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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The reliability rating was 1 because the study followed OECD 202/EU Method C.2 test guidelines and was performed under GLP.
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
GLP compliance:
yes
Analytical monitoring:
yes
Vehicle:
no
Test organisms (species):
Daphnia magna
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Remarks on exposure duration:
Water accommodated fractions (WAF) used
Reference substance (positive control):
no
Duration:
48 h
Dose descriptor:
EL50
Effect conc.:
> 5 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
nominal loading
Basis for effect:
other: immobilization
Remarks on result:
other: WAF
Duration:
48 h
Dose descriptor:
other: NOEL
Effect conc.:
> 5 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
nominal loading
Basis for effect:
other: immobilization
Remarks on result:
other: WAF
Validity criteria fulfilled:
yes
Conclusions:
The test substance did not cause any acute toxicity (i.e., immobilization or abnormal behavior) to Daphnia magna at the five concentrations tested including the highest 5008 mg/L loading exposure. The only immobilization was reported at 92 mg/L (1 out of 20 daphnids, questionable in light of all the other results). The 48-hr EL50 value was determined to be >5008 mg/L WAF. The NOEL (no observed effect loading) after 48 hr was estimated to be > 5008 mg/L WSF based on no immobilization at this loading. Hence, the test material is not expected to produce acute toxicity at its maximal water solubility level.
Executive summary:

The acute toxicity of the test material as measured by immobilization to the water flea,Daphnia magna, was evaluated in freshwater. Water accommodated fractions (WAFs) the test material did not produce any acute toxicity to Daphnia even at the highest nominal loadings of 5008 mg/L under the conditions of this study. It was determined that the 48 hr EL50 value was > 5008 mg/L WAF and the NOEL was > 5008 mg/L WAF since no significant immobilization or adverse effects were observed. Hence, the test material is not expected to produce acute toxicity at its maximal water solubility level in the WAF in this test.

Description of key information

The acute toxicity of the test material as measured by immobilization to the water flea, Daphnia magna, was evaluated in freshwater. Water accommodated fractions (WAFs) the test material did not produce any acute toxicity to Daphnia even at the highest nominal loadings of 5008 mg/L under the conditions of this study. It was determined that the 48 hr EL50 value was > 5008 mg/L WAF and the NOEL was > 5008 mg/L WAF since no significant immobilization or adverse effects were observed. Hence, the test material is not expected to produce acute toxicity at its maximal water solubility level in the WAF in this test.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
5 100 mg/L

Additional information

Conclusions:

The test substance did not cause any acute toxicity (i.e., immobilization or abnormal behavior) to Daphnia magna at the five concentrations tested including the highest 5008 mg/L loading exposure. The only immobilization was reported at 92 mg/L (1 out of 20 daphnids, questionable in light of all the other results). The 48-hr EL50 value was determined to be >5008 mg/L WAF. The NOEL (no observed effect loading) after 48 hr was estimated to be > 5008 mg/L WSF based on no immobilization at this loading. Hence, the test material is not expected to produce acute toxicity at its maximal water solubility level.