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EC number: 248-433-6 | CAS number: 27375-52-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- R: QSAR Toolbox 2.3.0.1132 prediction for LOEL read across evaluation for 27375-52-6
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- QSAR Toolbox version 2.3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
Test material
- Reference substance name:
- N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide
- EC Number:
- 248-433-6
- EC Name:
- N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide
- Cas Number:
- 27375-52-6
- Molecular formula:
- C10H13NO4S
- IUPAC Name:
- N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide
- Details on test material:
- - Name of test material (as cited in study report): N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- other: Rattus norvegicus
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 10 weeks
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5,10 and 25 mg/kg/day
Basis:
no data
- No. of animals per sex per dose:
- 25 male/female
- Control animals:
- not specified
Examinations
- Litter observations:
- Decreased litter size
Results and discussion
Results: F2 generation
Effect levels (F2)
- Dose descriptor:
- LOEL
- Generation:
- F2
- Effect level:
- 104.378 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: LOEL
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= -1.2
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.0487
Applicant's summary and conclusion
- Conclusions:
- The two generation reproductive toxicity LOEL (Lowest observed effect level) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in Rattus norvegicus was observed at a dose concentration of 104.378 mg/kg bw/day.This indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide shall not exhibit toxic effect to Rattus norvegicus below the above mention dose.
- Executive summary:
The two generation reproductive toxicity LOEL (Lowest observed effect level) of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide in Rattus norvegicus was observed at a dose concentration of 104.378 mg/kg bw/day.This indicates thatN-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide shall not exhibit toxic effect to Rattus norvegicus below the above mention dose.
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