3-(isotridecyloxy)propylamine

Endpoint summary

Description of key information

The oral LD50 of Etheramine C13i is within the range of 300-2000 mg/kg bw, with LD50 cut-off value of 500 mg/kg body weight.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

500 mg/kg bw

Additional information

Etheramine C13i was tested for acute oral toxicity according to acute toxic class method.

The incidence of mortality:  

Dose level	Mortality (day)	Sex	Clinical signs
300 mg/kg	1/3 (4)	females	Hunched posture, piloerection, lethargy, labored respiration, rales, watery discharge from the eye, chromodacryorrhoea and/or salivation (all animals). Full recovery day 6.
300 mg/kg	0/3	females
2000 mg/kg	3/3 (2-3)	females	Restless behaviour, lethargy, hunched posture, uncoordinated movements, shallow respiration, piloerection, diarrhoea, salivation, chromodacryorrhoea, lean appearance and/or ptosis (all animals).

The oral LD50 was established to be within the range of 300-2000 mg/kg body weight, with LD50 cut-off value of 500 mg/kg body weight.

Acute toxicity of comparable etheramines:

Substance	Alkyl chain	LD50 (mg/kgbw)	Ref.
Etheramine C13i	branched C13	500 (between 300-2000)
3-octyl/decyloxypropylamine	C8/C10	between200 and 2000	1
3-(2-ethylhexyl)oxypropylamine	branched C8	about 200	2
3-(C12-15-alkyl)oxypropylamine	C12-15	between200 and 2000	3

 

It seems that with shortening of the alkyl chain toxicity of the etheramines increases.

 

ref.:

1.    Acute Oral Toxicity to rats of Etheramine 810, Huntingdon Research Centre, 85292D/KND 4/AC, 1985-05-28

2.    Acute Oral Toxicity to rats of Etheramine 800 G, Huntingdon Research Centre, 85294D/KND 4/AC, 1985-04-25

3.    Acute Oral Toxicity to Rats of Etheramine 1215, Huntingdon Research Centre, 85293D/KND 4/AC, 1985-04-24

Acute dermal toxicity: Etheramine C13i is corrosive to the skin. Testing for acute dermal toxicity is therefore not justified. Toxicity following dermal exposure is characterised by local tissue damage, rather than the result of percutaneously absorbed material. For corrosive substances, the use of protective gloves and other equipment, such as face shields, aprons and good work practices are mandatory. Consequently, the occurrence of substantial dermal exposure of amounts comparable to the levels for acute oral toxicity is unlikely.

 

Acute inhalation toxicity: The substance is classified as corrosive and no acute toxicity testing should normally be conducted. As the substance is corrosive, symptoms of local respiratory irritation are expected, which should limit the systemic uptake of amount needed for systemic toxicity considering the relatively low acute oral toxicity.

Justification for classification or non-classification

The acute oral LD50 of Etheramine C13i is within the range of 300-2000 mg/kg bw. Hence the product should be classified according to GHS for acute toxicity as Cat.4, with hazard statement H302: Harmful if swallowed.

Acute dermal testing with corrosive materials is not justified. As a consequence no classification can be made for acute dermal toxicity. Effects will be characterised by local tissue damage. Systemic uptake via skin is likely to be very limited.

No classification for acute dermal toxicity is therefore indicated.

 

Also for acute inhalation toxicity information for classification is lacking, and is testing not justified.

 

Etheramine C13i does not contain aliphatic, alicyclic and aromatic hydrocarbons and have a relatively high viscosity and so do not indicate an immediate concern for aspiration hazard.