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EC number: 256-881-9 | CAS number: 50977-10-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The oral LD50 of Etheramine C13i is within the range of 300-2000 mg/kg bw, with LD50 cut-off value of 500 mg/kg body weight.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 500 mg/kg bw
Additional information
Etheramine C13i was tested for acute oral toxicity according to acute toxic class method.
The incidence of mortality:
Dose level |
Mortality (day) |
Sex |
Clinical signs |
300 mg/kg |
1/3 (4) |
females |
Hunched posture, piloerection, lethargy, labored respiration, rales, watery discharge from the eye, chromodacryorrhoea and/or salivation (all animals). Full recovery day 6. |
300 mg/kg |
0/3 |
females |
|
2000 mg/kg |
3/3 (2-3) |
females |
Restless behaviour, lethargy, hunched posture, uncoordinated movements, shallow respiration, piloerection, diarrhoea, salivation, chromodacryorrhoea, lean appearance and/or ptosis (all animals). |
The oral LD50 was established to be within the range of 300-2000 mg/kg body weight, with LD50 cut-off value of 500 mg/kg body weight.
Acute toxicity of comparable etheramines:
Substance |
Alkyl chain |
LD50 (mg/kgbw) |
Ref. |
Etheramine C13i |
branched C13 |
500 (between 300-2000) |
|
3-octyl/decyloxypropylamine |
C8/C10 |
between200 and 2000 |
1 |
3-(2-ethylhexyl)oxypropylamine |
branched C8 |
about 200 |
2 |
3-(C12-15-alkyl)oxypropylamine |
C12-15 |
between200 and 2000 |
3 |
It seems that with shortening of the alkyl chain toxicity of the etheramines increases.
ref.:
1. Acute Oral Toxicity to rats of Etheramine 810, Huntingdon Research Centre, 85292D/KND 4/AC, 1985-05-28
2. Acute Oral Toxicity to rats of Etheramine 800 G, Huntingdon Research Centre, 85294D/KND 4/AC, 1985-04-25
3. Acute Oral Toxicity to Rats of Etheramine 1215, Huntingdon Research Centre, 85293D/KND 4/AC, 1985-04-24
Acute dermal toxicity: Etheramine C13i is corrosive to the skin. Testing for acute dermal toxicity is therefore not justified. Toxicity following dermal exposure is characterised by local tissue damage, rather than the result of percutaneously absorbed material. For corrosive substances, the use of protective gloves and other equipment, such as face shields, aprons and good work practices are mandatory. Consequently, the occurrence of substantial dermal exposure of amounts comparable to the levels for acute oral toxicity is unlikely.
Acute inhalation toxicity: The substance is classified as corrosive and no acute toxicity testing should normally be conducted. As the substance is corrosive, symptoms of local respiratory irritation are expected, which should limit the systemic uptake of amount needed for systemic toxicity considering the relatively low acute oral toxicity.
Justification for classification or non-classification
The acute oral LD50 of Etheramine C13i is within the range of 300-2000 mg/kg bw. Hence the product should be classified according to GHS for acute toxicity as Cat.4, with hazard statement H302: Harmful if swallowed.
Acute dermal testing with corrosive materials is not justified. As a consequence no classification can be made for acute dermal toxicity. Effects will be characterised by local tissue damage. Systemic uptake via skin is likely to be very limited.
No classification for acute dermal toxicity is therefore indicated.
Also for acute inhalation toxicity information for classification is lacking, and is testing not justified.
Etheramine C13i does not contain aliphatic, alicyclic and aromatic hydrocarbons and have a relatively high viscosity and so do not indicate an immediate concern for aspiration hazard.
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