Registration Dossier
Registration Dossier
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EC number: 203-816-7 | CAS number: 110-93-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study with limited documentation from secondary source which meets basic scientific principles.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Fragrance Raw Materials Monographs
- Author:
- Opdyke DLJ
- Year:
- 1 975
- Bibliographic source:
- Fd. Cosm. Toxicol., 13, 859, 1975
- Reference Type:
- other: cited in RIFM FEMA Database, Location 2712
- Title:
- Acute toxicity study in rats and rabbits
- Author:
- Keating JW
- Year:
- 1 972
- Bibliographic source:
- cited in RIFM FEMA Database, Location 2712
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute dermal toxicity test in rabbits
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 6-methylhept-5-en-2-one
- EC Number:
- 203-816-7
- EC Name:
- 6-methylhept-5-en-2-one
- Cas Number:
- 110-93-0
- Molecular formula:
- C8H14O
- IUPAC Name:
- 6-methylhept-5-en-2-one
- Details on test material:
- - Name of test material (as cited in study report): 6-methyl-5-hepten-2-one
- Lot/batch No.: 72-35 (b1 1767)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: mortality and clinical signs
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- 1/6 deaths occurred on day 9
Any other information on results incl. tables
The present data on acute dermal toxicity do not fulfill the criteria laid down in 67/548/EEC and regulation (EU) 1272/2008, and therefore, a non-classification is warranted.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- based on CLP criteria
- Conclusions:
- Under the conditions of the test, the dermal LD50 was > 5000 mg/kg bw. Therefore, the substance does not need to be classified for acute toxicity in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
- Executive summary:
An acute dermal toxicity study was performed. Duration of observation period following administration: 14 days, mortality and clinical signs were examined.
Under the conditions of the test, the dermal LD50 was > 5000 mg/kg bw. Therefore, the criteria laid down in Annex I of the CLP Regulation (1272/2008/EC) are not fullfilled and the substance does not need to be classified for acute toxicity.
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