Registration Dossier
Registration Dossier
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EC number: 222-103-1 | CAS number: 3349-36-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The following studies have been submitted to address the short-term toxicity to aquatic invertebrates endpoint:
Priestly, SL & Mullee, DM, 2010. ACUTE TOXICITY TO DAPHNIA MAGNA. Testing laboratory: Harlan Laboratories Ltd, Shardlow Business, London Road, Shardlow, Derbyshire, DE72 2GD, UK. Report no.: 3103/0043. Owner company: Chemtura Corporation, 199 Benson Road, Middlebury, CONNECTICUT 06749, UNITED STATES OF AMERICA. As the study was performed on the test substance and conducted according to recognised guidelines and GLP, the study was assigned a reliability score of 1 and is suffiecient for assessment purposes.
Steger-Hartmann, T. & Schmidt, M. (1998). Acute immobilization test of di-n-butyltin oxide (ZK 26385) with Daphnia magna. Testing laboratory: Schering AG, Experimentelle Toxikologie, D-13342 Berlin, Germany. Report no.: IC26. Owner company: Schering AG, Experimentelle Toxikologie, Berlin, Germany. Study number: TXST19980203. Report date: 1998-12-03.
Result: The EC50 for 48 hours for di-n-butyltin oxide was determined to be 2.0 mg/l based on Total organic Carbon (TOC) concentration analysis. The highest concentration with no effect was 1.1 mg/l. As the study was performed on a read-across substance, the study was assigned a reliability score of 2.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.9 mg/L
Additional information
- The key study for this endpoint (Priestly & Mullee, 2010) was performed to assess the acute toxicity of the test item to Daphnia magna. The method followed that described in the OECD Guidelines for Testing of Chemicals (April 2004) No 202, "Daphnia sp, Acute Immobilisation Test" referenced as Method C.2 of Commission Regulation (EC) No. 440/2008.
The acute toxicity of the test item to the freshwater invertebrate Daphnia magna has been investigated and, based on 0-Hour measured concentrations as test item, gave a 48-Hour EC50 value of 1.9 mg/l with 95% confidence limits of 1.7 - 2.2 mg/l. The No Observed Effect Concentration at 48 hours was 1.2 mg/l.
Supporting information:
- Steger-Hartmann and Schmidt (1999) was performed in line with the appropriate guideline and to GLP but using dibutyltin oxide as the test material. The study has been allocated a Klimisch score of 2 and is included as a supporting study due to the fact that it is known that organotin ligand will hydrolyse to this form. The EC50 for 48 hours for di-n-butyltin oxide was determined to be 2.0 mg/l based on Total organic Carbon (TOC) concentration analysis. The highest concentration with no effect was 1.1 mg/l.
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