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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 233-823-0 | CAS number: 10377-52-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
There is no information available for trilithium orthophosphate concerning genotoxicity.
Concerning this endpoint, the lithium ion is considered to be the main toxophore, as phosphate ions are widely distributed throughout the organism (e.g. as structural material of bone and teeth and in form of adenosine phosphates ADP and ATP).
In a reverse mutation assay using Bacillus subtilis (rec assay) Lithium chloride was tested negative (Kanematsu et al.; Mutation Research 77: 109-116).
There is one study entry for Lithium hydroxide publicly available on the ECHA (European Chemicals Agency) homepage (disseminated dossier for lithium hydroxide), where the induction of chromosome aberrations in culture peripheral human lymphocytes was investigated. Under the conditions of this study, Lithium hydroxide was found to be non-clastogenic.
Léonard et al. reviewed the mutagenic potential of several lithium compounds (Lithium chloride, Lithium carbonate, Lithium acetate, Lithium sulphate). They concluded that lithium compounds have no significant clastogenic potential and equivocal mutagenic activity.
For Trilithium citrate, negative effects were reported from an Ames test with Salmonella typhimurium (34 µmol per plate), in the host-mediated assay with E.coli and in mice (4 mmol/kg i.p.).
The authors mentioned that high concentrations of Lithium carbonate (3 mg/ml) slightly inhibited DNA synthesis in V79 Chinese hamster cells and in human EUE fibroblasts. The effect is described to be lessened by the addition of S9 fraction.
There is also some information given concerning the experiences with Lithium-treated patients (as Lithium compounds are widely used in psychotherapy for the treatment of bipolar disorders). All the experiments failed to observe cytogenetic changes in peripheral blood cells of patients treated with Lithium salts (Mutation Research 339; 131-137; 1995).
Based on a weight of evidence approach, trilithium orthophosphate is not classified for genetic toxicity in accordance to Directive 67/548/EEC and in accordance to EU CLP (Regulation (EC) No. 1272/2008) and UN GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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