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Phenol, paraalkylation products with C12-rich branched olefins derived from propene oligomerisation, reaction products with sulphur monochloride and decene, reaction products with Benzoic acid, 2-hydroxy-,C14-18 alkyl dervis., polybutenyl benzenesulphonic acid, carbon dioxide and calcium hydroxide
EC number: 903-162-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 January to 08 February 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Compliant with current guidelines and GLP compliant
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Phenol, paraalkylation products with C12-rich branched olefins derived from propene oligomerisation, reaction products with sulphur monochloride and decene, reaction products with Benzoic acid, 2-hydroxy-,C14-18 alkyl dervis., polybutenyl benzenesulphonic acid, carbon dioxide and calcium hydroxide
- EC Number:
- 903-162-9
- IUPAC Name:
- Phenol, paraalkylation products with C12-rich branched olefins derived from propene oligomerisation, reaction products with sulphur monochloride and decene, reaction products with Benzoic acid, 2-hydroxy-,C14-18 alkyl dervis., polybutenyl benzenesulphonic acid, carbon dioxide and calcium hydroxide
- Details on test material:
- - Name of test material (as cited in study report): EC 903-162-9
- Physical state: Dark brown/black viscous liquid
- Analytical purity: Purity not applicable because the test item was a mixture of 100% UVCB Registration substance and solvent oil *
- Lot/batch No.: LN07006926
- Expiration date of the lot/batch: 19 December 2013
- Storage condition of test material: Ambient temperature, in the dark
*EC 903-162-9 is exclusively synthesised and handled in solvent oil. Therefore testing was conducted on a sample that contained 40.8% Base oil and 59.2% EC 903-162-9.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Born at Charles River, Edinburgh
- Age at study initiation: Approximately 9 months old
- Weight at study initiation: 4.525 kg and 4.127 kg
- Housing: Singly housed
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18°C on each day
- Humidity (%): 42% to 58%
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12 hrs light / 12 hrs dark
IN-LIFE DATES: From: To: 29 January to 08 February 2013
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL
- Concentration (if solution): Not applicable - Duration of treatment / exposure:
- Single dose
- Observation period (in vivo):
- 72 h
- Number of animals or in vitro replicates:
- Two
- Details on study design:
- REMOVAL OF TEST MATERIAL
- Washing (if done): None
SCORING SYSTEM:
OECD Test Guideline scoring system
TOOL USED TO ASSESS SCORE: Hand held magnifier and pen torch (when necessary). When required only, fluorescein and ultraviolet illumination
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable
- Other effects:
- Slight ocular discharge at 1 h and 4 h post instillation
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Using the criteria described in regulation (EC) 1272/2008, under the conditions of the study, EC 903-162-9 would be considered to be non-irritating to the rabbit eye.
This study is considered to be relevant, reliable and adequate for risk assessment and for classification purposes. - Executive summary:
- This study investigated the eye
irritation potential of EC-903-162-9 after a single instillation to the
rabbit eye.
Two female rabbits received 0.1 mL of EC-903-162-9, instilled, as supplied, into the conjunctival sac of the right eye. The left eye remained untreated and hence it acted as a control. Both eyes were examined for evidence of irritation approximately 1, 4, 24, 48 and 72 h after instillation.
No irritation was noted in the control eyes of either rabbit at any observation timepoint.
There were no reactions in the iris of either animal. Corneal opacity, slight conjunctival redness and a slight discharge were noted 1 h after test item instillation in one animal. However, after the eye was stained with Fluorescein and the eye examined under ultraviolet illumination, no area of opacity was found. Slight discharge was noted 4 h after test item instillation in both animals.
Using the criteria described in the European Union Council Directive 67/548/EEC and Regulation (EC) No 1272/2008 (CLP) under the conditions of the study, EC-903-162-9 would be considered to be non-irritating to the rabbit eye.
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