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EC number: 204-516-9 | CAS number: 122-03-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: The LD50 value was determined to be 1390 mg/kg (male/female).
Acute dermal toxicity: The LD50 value was determined to be 2800 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP and guideline compliant study.
- Principles of method if other than guideline:
- No data about the method available
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: Young adult
- Weight at study initiation: No data
- Fasting period before study: 18 hr - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data
- Doses:
- No data
- No. of animals per sex per dose:
- 5 animals
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs, body weight,organ weights - Statistics:
- LD50 was computed by the method of Litchfield & Wilcoxon.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 390 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 140 - < 1 700
- Mortality:
- Mortality occured after 4hr - 10 days (most deaths within 2 days).
- Clinical signs:
- other: Depression within 1 hr after treatment, porphyrin-like deposit around eyes and nose.
- Gross pathology:
- Gross pathology showed discoloured live, irritated gastro- intestinal tract, stomach haemorrhage, yellowish material attached to the intestines.
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance is harmful if swallowed. The LD50 value was determined to be 1390 mg/kg (male/female).
- Executive summary:
The acute oral toxicity test was conducted with 10 young adult Osborne-Mendel rats evenly divided by sex. The animals were fasted approximately 18 hours prior to treatment. All doses were given by intubation. The animals were maintained under close observation for recording toxic signs and time of death. Such observation was continued until animals appeared normal and showed weight gain. The usual observation period was 2 weeks. Following observations were made: Depression within 1 hour after treatment, scrawny appearance, porphyrin-like deposit around eyes and nose. Gross pathology examinations showed discoloured liver, irritated gastro- intestinal tract, stomach haemorrhage, yellowish material attached to the intestines.
The LD50 value was determined to be1390 mg/kg (male/female).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 390 mg/kg bw
- Quality of whole database:
- No GLP and guideline compliant study.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 800 mg/kg bw
- Quality of whole database:
- No GLP and guideline compliant study.
Additional information
Acute oral toxicity:
The acute oral toxicity test was conducted with 10 young adult Osborne-Mendel rats evenly divided by sex. The animals were fasted approximately 18 hr prior to treatment. All doses were given by intubation. The animals were maintained under close observation for recording toxic signs and time of death. Such observation was continued until animals appeared normal and showed weight gain. The usual observation period was 2 weeks. The observations were depression within 1 hr after treatment, scrawny appearance, porphyrin-like deposit around eyes and nose. Gross pathology showed discoloured live, irritated gastro- intestinal tract, stomach haemorrhage, yellowish material attached to the intestines.
The LD50 value was determined to be1390 mg/kg (male/female).
Acute dermal toxicity:
In Denine, 1973 (Report to RIFM, 12 April) the acute dermal LD50 in rabbits of 2800 mg/kg was reported.
Justification for selection of acute toxicity – oral endpoint
Available study
Justification for selection of acute toxicity – dermal endpoint
Available data.
Justification for classification or non-classification
Based on the result of the acute oral toxicity test the test substance has to be classified as Cat.4 H302: Harmful if swallowed according to Regulation (EC) No 1272/2008 (CLP) and as Acute Tox.4, respectively Xn;R22: Harmful if swallowed according to the criteria of Directive 67/548/EEC (DSD).
Based on the result of the acute dermal toxicity test to the test substance, classification is not warranted according to the criteria of Directive 67/548/EEC (DSD) and Regulation (EC) No 1272/2008 (CLP).
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