Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-702-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
2 moles Ethoxylated bisphenol A methacrylate was examined for primary skin and eye irritating properties in experiments with albino rabbits (TNP 1975) : the substance is not irritating for skin or eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Primary irritation to the skin is measured by a patch-test technique on the abraded and intact skin albino rabbits.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Healthy adult rabbits.
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and intact skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- An amount of 0.5 ml of the tes substance is brought on the intact or abraded skin under a surgical patch measuring 1 inch x 1 inch.
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 and 72 hours after application.
- Number of animals:
- 12 (6 with abraded skin, and 6 with intact skin)
- Details on study design:
- The patches are fiwed to the application site by means of adhesive tape and the entire trunk of the rabbits is wrapped with an impervious material to maintain the test patches in position and to retard evaporation of volatile substances.
Six rabbits are treated on the intact skin, the other six on the abraded skin. The abrasions are minor incisions through the stratum corneum, but not sufficiently deep to disturb the derma or to produce bleeding.
After an exposure period of 24 hours the patches and the material applied are removed and the resulting skin reactions are evaluated by the method of Draize. A second reading is made 48 hours later (72 hours after application). - Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 6 rabbits with intact skin
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: (intact skin) 5 animals out of 6 have an erythema score of 1 at 24 hours.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 6 rabbits with intact skin
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: (intact skin) No oedema observed in all the animals.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 6 rabbits with abraded skin
- Time point:
- 24/48/72 h
- Score:
- 1.1
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: (abraded skin) Maximal score of 2 is observed at 24 hours in 5 rabbits.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 6 rabbits with abraded skin
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: (abraded skin) no oedema observed in all the animals.
- Irritant / corrosive response data:
- The two products examined caused very slight skin irritation on the intact skin and slight irritation on the abraded skin.
After 72 hours no dermal effects were detectable on the intact application sites. Only two out of 6 animals treated on the abraded skin showed very slight scaliness of the treated skin. - Other effects:
- no data
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Not skin irritating
- Conclusions:
- Based on the results on intact skin, 2 moles Ethoxylated bisphenol A methacrylate is considered to be not skin irritating.
- Executive summary:
2 moles Ethoxylated bisphenol A methacrylate was examined for primary skin irritating properties. Primary irritation to the skin is measured by a patch-test technique on the abraded and intact skin albino rabbits. After an exposure period of 24 hours, the patches and the material applied are removed and the resulting skin reactions are evaluated by the method of Draize. A second reading is made 48 hours later.
Based on the results on intact skin, 2 moles Ethoxylated bisphenol A methacrylate is considered to be not skin irritating.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 2 moles Ethoxylated bisphenol A methacrylate was examined for eye irritating properties according to the techniques of tests published by the FDA of the US and Draize and Kelley.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Healthy adult rabbits.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the other eye remaining untreated serves as a control
- Amount / concentration applied:
- One tenth of a milliliter of the test substance is allowed to fall on the overted lower lid of one eye of each rabbit; the upper and lower eye lid are then cared fully closed and subsequently held together for as least one second before releasing, to prevent loss of material.
- Duration of treatment / exposure:
- one administration
- Observation period (in vivo):
- 24-48-72 hours and 7 fays after instillation of the test material.
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- The eyes are not washed following instillation and the animals are released immediately.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Test substance did not elicit any detectable eye lesions.
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Not eye irritating
- Conclusions:
- 2 moles Ethoxylated bisphenol A methacrylate did not elicit any detectable eye lesions; it is considered to be not irritating for eyes.
- Executive summary:
2 moles Ethoxylated bisphenol A methacrylate was examined for eye skin irritating properties according to the Draize method.
0.1 mL of the test substance is allowed to fall on the eye. The eyes are not washed following instillation and the animals are released immediately. The eyes are examined at 24, 48, 72 hours and 7 fays after instillation of the test material.
2 moles Ethoxylated bisphenol A methacrylate did not elicit any detectable eye lesions; it is considered to be not irritating for eyes.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation (TNO 1975)
2 moles Ethoxylated bisphenol A methacrylate was examined for primary skin irritating properties. Primary irritation to the skin is measured by a patch-test technique on the abraded and intact skin albino rabbits. After an exposure period of 24 hours, the patches and the material applied are removed and the resulting skin reactions are evaluated by the method of Draize. A second reading is made 48 hours later.
Based on the results on intact skin, 2 moles Ethoxylated bisphenol A methacrylate is considered to be not skin irritating.
Eye irritation (TNO 1975)
2 moles Ethoxylated bisphenol A methacrylate was examined for eye skin irritating properties according to the Draize method.
0.1 mL of the test substance is allowed to fall on the eye. The eyes are not washed following instillation and the animals are released immediately. The eyes are examined at 24, 48, 72 hours and 7 fays after instillation of the test material.
2 moles Ethoxylated bisphenol A methacrylate did not elicit any detectable eye lesions; it is considered to be not irritating for eyes.
Justification for classification or non-classification
Based on the available data, no classification for skin or eye irritation is required for 2 modes ethoxylated bisphenol A dimethacrylate according to the Regulation EC N°1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.