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Diss Factsheets
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EC number: 203-265-2 | CAS number: 105-05-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The substance has no structural alerts for mutagenicity. All three in vitro tests in genetic toxicity (GLP compliant and scored Klimishch 1) showed negative results up to the cytotoxic concentrations. Thus there is no need to carry out in vivo studies in genetic toxicity. There is no reason to believe that the negative results would not be relevant to humans.
Justification for selection of genetic toxicity endpoint
No specific study was selected because all three available in vitro studies were negative. Conclusions are based on the following assays: Bacterial reverse mutation assay (Ames test); Mammalian cell gene mutation assay; In vitro mammalian chromosome aberration test.
Short description of key information:
The results of in vitro studies are negative, both with and without metabolic activation:
- Ames test with S. typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1539 and E coli WP2 uvrA (met. act.: with and without) (OECD TG 471 and 472 and GLP); no toxicity was observed up to a concentration of 50 µg/plate.
- Mammalian cell gene mutation assay with Chinese hamster lung fibroblasts (V79) (met. act.: with and without) (OECD Guideline 476 and GLP); cytotoxicity: preliminary toxicity tests showed a cytotoxicity of 100 µg/mL . The experiments resulted on negative results (no adverse effect observed) up to the 100 µg/mL.
- In vitro mammalian chromosome aberration test with Chinese Hamster Lung (CHL) cells (met. act.: with and without) (OECD Guideline 473 and GLP); cytotoxicity: either structural chromosomal aberrations or polyproidy were not recognized up to a maximum concentration of 0.11 mg/ml (without metabolic activation) and 1.3 mg/ml (with metabolic activation)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Directive 67/548/EEC, Annex 1 and Regulation EC 1272/2008, Annex VI: 1,4 -diethylbenzene is not classified.
Following the criteria as described in Directive 67/548/EEC and Annex 1 of Regulation (EC) No. 1272/2008, and based on the available data, 1,4 -diethylbenzene is not classified for endpoint Germ cell mutagenicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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