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EC number: 617-708-6 | CAS number: 85390-94-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-08-05 to 2002-08-22
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- yes
- Principles of method if other than guideline:
- At pH values where more than 10 % degradation was observed under the conditions of the preliminary test (5 days at 50 °C), experiments at elevated temperatures were necessary in order to extrapolate from the hydrolysis rate constants determined at elevated temperatures to the hydrolysis rate constant at 25 °C. Those experiments were conducted only at one elevated temperature instead of two elevated temperatures. This is justified since acceptable results were obtained. At pH 9, only one insted of two experiments were conducted.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 7 beta-Hydroxy-3 beta,15 alpha-dipivaloyloxy-5-androsten-17-one
- EC Number:
- 617-708-6
- Cas Number:
- 85390-94-9
- Molecular formula:
- C29 H44 O6
- IUPAC Name:
- 7 beta-Hydroxy-3 beta,15 alpha-dipivaloyloxy-5-androsten-17-one
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
Duration of testopen allclose all
- Duration:
- 190.1 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.45 mg/L
- Duration:
- 6 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.432 mg/L
- Duration:
- 16.2 h
- pH:
- 4
- Temp.:
- 80 °C
- Initial conc. measured:
- 0.45 mg/L
- Duration:
- 2.08 h
- pH:
- 7
- Temp.:
- 80 °C
- Initial conc. measured:
- 0.432 mg/L
- Duration:
- 8.5 h
- pH:
- 9
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.309 mg/L
Results and discussion
- Transformation products:
- not measured
Any other information on results incl. tables
The rate of hydrolysis increases with pH. The half-life at 25 °C decreases from 50 days at pH 4
to 1.9 hours at pH 9. The hydrolysis is therefore base-catalyzed.
Two ester functions are present in the molecule leading to three possible hydrolysis products by
cleavage of one of the ester functions or of both of them. One of the products can be identified
by a peak at 3.3 min in the chromatograms of the hydrolysis solutions at pH 7. This peak
appears to be the final hydrolysis product ZK 91535 since its area increases steadily with
hydrolysis time.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
The rate of hydrolysis of ZK 92136 was determined at pH 4, 7 and 9.
The rate constants and half-lives at 25 °C are:
pH k [1/h] 95 % confidence intervalsfor k [1/h] half-life 95 % confidenceintervals for half-life 4 5.803 E-04 5.061 E-04 to 6.545 E-04 50 d 44 to 57 d 7 1.182 E-02 7.760 E-03 to 1.588 E-02 58.6 h 43.6 to 89.3 h 9 0.3668 0.2837 to 0.4498 1.9 h 1.5 to 2.4 h
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