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EC number: 242-894-7 | CAS number: 19224-26-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 May 2014 to 03 October 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed to GLP and current guidelines
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil
- Radiolabelling:
- no
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Agilent 1200 Series Liquid Chromatograph with Chemstation software
- Type, material and dimension of analytical (guard) column: HyperClone CN (CPS) (25 cm x 4.6 mm internal diameter)
- Detection system: UV set at 210 nm
MOBILE PHASES
- Type: Methanol: Water (55:45 v/v)
DETERMINATION OF DEAD TIME
- Method: An internal standard (formamide) with no retention on the HPLC column was used to determine the deadtime of the HPLC system.
REFERENCE SUBSTANCES
- Identity:Acetanilide, Nitrobenzene, Naphthalene, 2-Methylnaphthalene, Anthracene, DDT
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 50 mg/L
- Quantity of reference substances:
Internal deadtime standard (I.D.S.) 217 mg/L
Acetanilide 10.1mg/L
Nitrobenzene 10.1mg/L
Naphthalene 2.70mg/L
Anthracene 10.0mg/L
DDT 10.0mg/L
2-Methylnaphthalene 2.70mg/L
REPETITIONS
- Number of determinations: 2 - Key result
- Type:
- Koc
- Value:
- 4 400
- Temp.:
- 25 °C
- Key result
- Type:
- log Koc
- Value:
- 3.6
- Temp.:
- 25 °C
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration:
Component Run A Run B
tr (minutes) tr (minutes)
Acetanilide 3.569 3.567
Nitrobenzene 4.319 4.316
Naphthalene 5.381 5.378
2-Methylnaphthalene 6.094 6.090
Anthracene 8.520 8.516
DDT 15.706 15.702
PGDB 6.264 6.263
- Linear regression (based on mean of standard runs A and B): log10Koc = 3.36 log10k + 3.48
- Average retention data for test substance: 6.264 minutes - Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance, propylene glycol dibenzoate, was found to have a log10Koc value of 3.6.
- Executive summary:
The test substance, propylene glycol dibenzoate, was found to have a log10Koc value of 3.6.
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 5 June 1997 - 21 August 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented study conducted to GLP and to an OECD Draft Document
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- other: HPLC is performed on commercially available analytical columns packed with a solid phase containing a moderately polar stationary phase with lipophilic and polar moieties, e.g. cyano propyl bonded phase.
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Vapour pressure:1.2E-06 mm Hg @ 25°C
- Water solubility*: 8.69 mg/L
- log Pow*: 3.9 - Radiolabelling:
- no
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus:
- Type: HPLC instrument: Hewlett Packard HP 1050 Series
- Type, material and dimension of analytical column: Hypersil 5 µm CPS (25 cm x 4.6 mm internal diameter)
- Detection system: UV at 230 nm
MOBILE PHASES
- Type: Methanol:water (55:45 v/v)
- Experiments with additives carried out on separate columns: None reported
pH: Not stated
DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column (see below)
REFERENCE SUBSTANCES
- Identity:
. IDS - Deadtime only (300 mg/L) Formamide, Internal Deadtime Standard
. Phenol (42 mg/L)
. Trichloroethylene (54 mg/L)
. Bromobenzene (66 mg/L)
. Anthracene (5.9 mg/L)
. Pyrene (3.2 mg/L)
. p,p'-DDT (29 mg/L)
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: a solution approx. 8 mg/L
- Quantity of reference substances: see above
REPETITIONS
- Number of determinations: 3
EVALUATION
- Calculation of capacity factors k': In order to correlate the measured capacity factor (k) ofthe test material with its Koc, six reference materials were selected from a list ofrecommended compounds. These reference compounds were selected to have log10Koc values in the range 1.3 to 5.4.
An internal standard (formamide) with no retention on the HPLC column was used to determine the deadtime ofthe HPLC system.
- Key result
- Type:
- Koc
- Value:
- 3 981
- Temp.:
- 20 °C
- Remarks on result:
- other: HPLC
- Key result
- Type:
- log Koc
- Value:
- 3.6
- Temp.:
- 20 °C
- Remarks on result:
- other: HPLC
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- A value of log10Koc for DPGDB of 3.6 was obtained (equivalent Koc - 3.981 x 10^3).
- Executive summary:
Key data is available for propylene glycol dibenzoate (PGDB). This data is supported by relevant information available from a structural analogue Dipropylene glycol dibenzoate (DPGDB). The justification for read across is presented as an attachment included in Section 13 of the IUCLID dossier
A reference mixture containing formamide (an Internal Deadtime Standard) was injected before and after the DPGDB sample solution (in mobile phase).
From the calibration curve generated from the reference mixture the log10Koc of DPGDB could be interpolated. A value of log10Koc for DPGDB of 3.6 was obtained (equivalent Koc = 3.981 x 103).
Referenceopen allclose all
Description of key information
Key data is available for propylene glycol dibenzoate (PGDB). This data is supported by relevant information available from a structural analogue Dipropylene glycol dibenzoate (DPGDB). The justification for read across is provided as an attachment included in Section 13 of the IUCLID dossier.
Propylene glycol dibenzoate was determined to have a log10Koc value of 3.6 (equivalent Koc = 4.4 x 103) at 25°C in a GLP study performed to internationally accepted guidelines (Huntingdon Life Sciences, 2014a; Klimisch Score = 1).
Dipropylene glycol dibenzoate was determined to have a log10Koc value of 3.6 (equivalent Koc = 3.981 x 103) at 20°C (Huntingdon Life Sciences, 1999b; Klimisch Score = 1).
Key value for chemical safety assessment
- Koc at 20 °C:
- 4 400
Additional information
Log Koc: 3.6
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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