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EC number: 223-276-6 | CAS number: 3806-34-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 10 November 1977 to 24 November 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A non-GLP study performed to sound scientific principles with a sufficient level of detail to assess the quality of the submitted data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- (exposure duration 1 hour rather than 4 hours)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- O,O'-dioctadecylpentaerythritol bis(phosphite)
- EC Number:
- 223-276-6
- EC Name:
- O,O'-dioctadecylpentaerythritol bis(phosphite)
- Cas Number:
- 3806-34-6
- Molecular formula:
- C41H82O6P2
- IUPAC Name:
- 3,9-bis(octadecyloxy)-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adult
- Weight at study initiation: 225 g (average)
- Housing: individually
- Diet: ad libitum (except during exposure period)
- Water: ad libitum (except during exposure period)
- Acclimation period: 3 days
IN-LIFE DATES: From 10 November 1977 to 24 November 1977
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: specially constructed, all plexiglas inhalation chambers
- Exposure chamber volume: 355 cubic litres
- Method of holding animals in test chamber: Each animal was placed in a separate wire cage during exposure to prevent filtration of inspired air by animals fur
- System of generating test atmosphere: The chamber was equipped with blowers so that after the test material was introduced into the chamber's atmosphere the air was continually recirculating during the test period
TEST ATMOSPHERE
The average nominal test material concentration was calculated by dividing the total amount of test material used by the total volume of the chamber - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 1 h
- Concentrations:
- 2 mg/L
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: all animals were weighed at study initiation and then again on day 14
- Necropsy of survivors performed: yes
- Other examinations performed: a gross pathological autopsy was conducted on all animals found dead during the study as well as on all surviving animals
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- None of the animals died during the study.
- Clinical signs:
- other: All animals appeared normal during the 14 day period.
- Body weight:
- All of the animals gained weight during the study.
- Gross pathology:
- The organs of the thorax and abdomen appeared normal at gross pathology.
Any other information on results incl. tables
Table 1: Results
Animal no. and sex |
Initial bodyweight (g) |
Dose (mg/L) |
Weight gain in 14 days (g) |
Days to death |
1F |
204 |
2 |
46 |
survived |
2F |
201 |
2 |
78 |
survived |
3F |
210 |
2 |
60 |
survived |
4F |
202 |
2 |
70 |
survived |
5F |
206 |
2 |
60 |
survived |
6M |
228 |
2 |
102 |
survived |
7M |
242 |
2 |
106 |
survived |
8M |
232 |
2 |
130 |
survived |
9M |
236 |
2 |
112 |
survived |
10M |
254 |
2 |
136 |
survived |
Applicant's summary and conclusion
- Interpretation of results:
- other: LC50 in excess of 2 mg/L (1 h) (highest dose level tested), the classification of the test material cannot be interpreted based on the results of the study
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute inhalation LC50 was determined to be greater than 2 mg/L of atmosphere for a one hour exposure period to the test material.
- Executive summary:
The acute inhalation toxicity of the test material was determined following a methodology similar to that outlined in the standard guideline OECD 403. During the study, 5 male and 5 female rats were exposed to atmospheres containing test material at 2 mg/L for 1 hour. During the exposure period, mortality and signs of reaction to the test material were assessed. Following exposure the animals were returned to their cages where they were observed for 14 days. At the end of the 14 day exposure period all animals were subject to a gross pathological examination.
Under the conditions of the study, none of the animals died. All animals appeared normal during the 14 day observation period and gross necropsy revealed that the organs of the thorax and abdomen appeared normal. The acute inhalation LC50 was therefore determined to be greater than 2 mg/L of atmosphere for a one hour exposure period to the test material.
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