Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 243-887-1 | CAS number: 20570-96-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: predicted data
- Title:
- 25.12.2012 17:50 [R]: 1.55E3 mg/kg bw "Human Health Hazards#Acute Toxicity" for 20570-96-1
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- QSAR Toolbox version 3.0
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no information on method;OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Data is predicted by QSAR toolbox version 2.3, ;Directive 92/69/EEC, B.1;Directive 92/69/EEC, B.3;OECD Guideline 402 (Acute Dermal Toxicity);EU Method B.1 (Acute Toxicity (Oral)) Cited as Directive 84/449/EEC, B.1;84/449/EWG (Official Journal)
- GLP compliance:
- no
- Test type:
- other: LD50;standard acute method;no data
Test material
- Reference substance name:
- Benzylhydrazine dihydrochloride
- EC Number:
- 243-887-1
- EC Name:
- Benzylhydrazine dihydrochloride
- Cas Number:
- 20570-96-1
- Molecular formula:
- C7H10N2.2ClH
- IUPAC Name:
- benzylhydrazine dihydrochloride
- Details on test material:
- Substance name - Benzylhydrazine dihydrochloride
Substance type : organic
Molecular Formula: C7H10N2
SMILES:c1(CNN)ccccc1_Cl_Cl
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 545.075 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 4 nearest neighbours
Domain logical expression:Result: In Domain
(((((("a" and "b" ) and ("c" and ( not "d") ) ) and "e" ) and "f" ) and ("g" and ( not "h") ) ) and ("i" and "j" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(CNN)ccccc1_Cl_Cl
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Similarity boundary:Target: c1(CNN)ccccc1_Cl_Cl
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as No alert found by Protein binding alerts for skin sensitization by OASIS v1.1
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as Acylation OR Acylation >> Acyl transfer via nucleophilic addition reaction OR Acylation >> Acyl transfer via nucleophilic addition reaction >> Isocyanates and isothiocyanates OR Acylation >> Direct acylation involving a leaving group OR Acylation >> Direct acylation involving a leaving group >> N-acylamides OR Michael addition OR Michael addition >> Michael addition on conjugated systems with electron withdrawing group OR Michael addition >> Michael addition on conjugated systems with electron withdrawing group >> Cyanoalkenes OR Michael addition >> Michael type addition on vinyl pirydines and activated ethenylarenes OR Michael addition >> Michael type addition on vinyl pirydines and activated ethenylarenes >> Vinyl pyridines OR SN2 OR SN2 >> Interchange reaction with sulphur containing compounds OR SN2 >> Interchange reaction with sulphur containing compounds >> Thiols and disulfide compounds OR SN2 >> Nucleophilic substitution on benzylic carbon atom OR SN2 >> Nucleophilic substitution on benzylic carbon atom >> alpha-activated benzyls by Protein binding alerts for skin sensitization by OASIS v1.1
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as No superfragment by Superfragments
Domain logical expression index: "f"
Referential boundary: The target chemical should be classified as Biodegrades Fast by Biodeg probability (Biowin 1)
Domain logical expression index: "g"
Referential boundary: The target chemical should be classified as Not classified by Oncologic Primary Classification
Domain logical expression index: "h"
Referential boundary: The target chemical should be classified as Aromatic Amine Type Compounds OR Halogenated Aromatic Hydrocarbon Type Compounds OR ortho-Haloganated Heterocyclic Type Compounds OR Phenol Type Compounds by Oncologic Primary Classification
Domain logical expression index: "i"
Parametric boundary:The target chemical should have a value of log Kow which is >= 0.346
Domain logical expression index: "j"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.665
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Toxicity Category IV LD50 > 300 mg/kg and < 2000 mg/kg;Toxicity Category IV LD50 > 300 and < 2000 mg/kg;harmful;not classified Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of Benzylhydrazine dihydrochloride in Rat Sprague-Dawley was estimated to be 1545.07 mg/kg bw.
- Executive summary:
The acute oral median lethal dose (LD50) of Benzylhydrazine dihydrochloride in Rat Sprague-Dawley was estimated to be 1545.07 mg/kg bw.This value indicates that Benzylhydrazine dihydrochloride exhibits acute toxicity by the oral route in category 4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.