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EC number: 600-026-8 | CAS number: 1000817-22-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on preparation and application of test substrate:
- - Method of mixing into soil (if used): About 10 g of a mixture of fine ground quartz sand and 550 mg of test substance were mixed with 740g wet artificial soil for each test container to form a test substance concentration of 1000 mg/kg dry weight.
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Common name: earthworm
- Source: Zhuhai Hongming Earthworm Breeding park
- Age at test initiation (mean and range, SD): > 2 months
- Weight at test initiation (mean and range, SD): 552 - 571 mg
ACCLIMATION
- Acclimation period: 14d
- Acclimation conditions (same as test or not): same as test
- Health during acclimation (any mortality observed): no mortality observed - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Test temperature:
- 18.3 - 21.6 °C
- pH:
- 6.84 - 6.89
- Moisture:
- 25.55 - 29.65%
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): 1L glass beaker
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 4
- No. of replicates per control: 4
OTHER TEST CONDITIONS
- Photoperiod: continuous light
- Light intensity: 554 lux (at the beginning) and 511 lux at the end of the test
EFFECT PARAMETERS MEASURED: Weight, behavior and mortality were recorded after 77 and 14 days exposure time. - Nominal and measured concentrations:
- Nominal: 1000 mg/kg dw
- Reference substance (positive control):
- yes
- Remarks:
- Cloracetamide
- Key result
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Mortality at end of exposure period: none
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Relevant effect levels: 14d-LC50 was 19.71 mg/kg dry weight, and the 95% confidence Iimit was between 18.14 and 21.42 mg/kg dry weight, which was within the range of 10 - 100 mg/kg dry weight. - Validity criteria fulfilled:
- yes
- Conclusions:
- the substance is not acutely harmful to earthworms.
Reference
Description of key information
LC50(14d) > 1000 mg/kg dw (nominal) for Eisenia foetida (OECD 207)
Key value for chemical safety assessment
Additional information
One study investigating the short-term toxicity of Fatty acids, C8-18 and C18-unsatd., reaction products with diethanolamine and propylene oxide (CAS 1000817-22-0) to earthworms is available. The study was performed according to OECD guideline 207 under GLP conditions (Liu 2013). A test substance concentration of 1000 mg/kg dw soil was tested in a limit test using Eisenia foetida as test organism. No mortality was observed in control and treatment throughout the test duration of 14 days. Thus, the 14d-LC50 is determined to be > 1000 mg/kg dw soil based on nominal concentrations.
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