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EC number: 210-039-7 | CAS number: 603-41-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-01-13 to 2003-04-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted under GLP conditions in accordance with the official OECD guideline No 301 F (1992)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- (1992)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Version / remarks:
- (1992)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 846867
Test material
- Reference substance name:
- p,p'-(2-pyridylmethylene)bisphenol
- EC Number:
- 210-039-7
- EC Name:
- p,p'-(2-pyridylmethylene)bisphenol
- Cas Number:
- 603-41-8
- Molecular formula:
- C18H15NO2
- IUPAC Name:
- 4-[(4-hydroxyphenyl)(pyridin-2-yl)methyl]phenol
- Test material form:
- solid
1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): supplied by wastewater treatment plant ARA Ergolz II, Füllinsdorf, Switzerland- The sludge was washed twice with tap water by centrifugation and the supernatant liquid phase was decanted. A homogenized aliquot of the final sludge suspension was weighed, thereafter dried and the ratio of wet to dry weight was calculated. Based on this ratio, calculated amounts of wet sludge were suspended in test water to obtain a concentration equivalent to 4 g (+-10%) dry material per liter. During holding, the sludge was aerated at room temperature until use. Prior to use, the sludge was diluted with test water to a concentration of 1 g per liter (dry weight basis). This diluted activated sludge was used as inoculum to give a final concentration of 30 mg dry material per liter.
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS- Composition of medium: The test water was prepared according to testing guideline. Grade salts were added to deionised water to give stock solution. Stock solutions were diluted in deionised water. In order to avoid having to prepare solution FeCl3 x 6H2O 0.25 g/L immediately before use, one drop of concentrated HCl per liter was added.- Test temperature: none given - pH: 7.3-7.7- pH adjusted: yes, the pH of the final test water was adjusted from 7.8 to 7.4 with a diluted hydrochloric acid solution.TEST SYSTEM- Number of culture flasks/concentration: 2 (test item)- Method used to create aerobic conditions: during holding, the sludge was aerated at room temperature until use.CONTROL AND BLANK SYSTEM- Inoculum blank: yes- Toxicity control: yes
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
- Test performance:
- The validity criteria of the method were fulfilled. No unusual observations during testing.
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 3
- Sampling time:
- 28 d
- Remarks on result:
- other: mean value
BOD5 / COD results
- Results with reference substance:
- The percent biodegradation of the reference item sodium benzoate was calculated based on the theoretical oxygen demand of 1.67 mg/O2/mg. In the procedure controls, the reference item was degraded by an average of 85 % by exposure day 14, thus confirming suitability of the activated sludge. At the end of the test (Day 28), the reference item was degraded by an average of 93 %.
Any other information on results incl. tables
Table 1: Cumulative biochemical oxygen demand (BOD mg O2/L) in the flask
Time (days) | Test item | Procedure control | Toxicity control | ||
| Flask No. | Flask No. | Flask No. | ||
| 5 | 6 | 3 | 4 | 7 |
0 | 0 | 0 | 0 | 0 | 0 |
1 | 0 | 0 | 37 | 36 | 40 |
2 | 0 | 0 | 94 | 94 | 95 |
3 | 0 | 0 | 103 | 104 | 103 |
4 | 2 | 3 | 112 | 114 | 113 |
5 | 4 | 5 | 122 | 123 | 123 |
6 | 6 | 6 | 129 | 130 | 130 |
7 | 6 | 7 | 134 | 134 | 134 |
8 | 8 | 8 | 138 | 138 | 138 |
9 | 8 | 9 | 141 | 142 | 141 |
10 | 10 | 11 | 145 | 146 | 144 |
11 | 12 | 12 | 147 | 148 | 147 |
12 | 14 | 13 | 150 | 152 | 149 |
13 | 14 | 15 | 152 | 154 | 152 |
14 | 16 | 15 | 154 | 156 | 154 |
15 | 16 | 16 | 157 | 160 | 157 |
16 | - | - | - | - | - |
17 | 18 | 17 | 161 | 162 | 160 |
18 | 18 | 18 | 163 | 164 | 162 |
19 | 20 | 19 | 165 | 166 | 164 |
20 | 20 | 19 | 166 | 166 | 165 |
21 | 20 | 20 | 168 | 168 | 166 |
22 | 20 | 21 | 169 | 168 | 167 |
23 | 20 | 21 | 169 | 168 | 167 |
24 | 21 | 21 | 170 | 168 | 168 |
25 | 23 | 22 | 172 | 170 | 169 |
26 | 23 | 23 | 172 | 170 | 170 |
27 | 23 | 23 | 172 | 172 | 171 |
28 | 23 | 24 | 173 | 172 | 172 |
The percentage biodegradation was calculated according to the below given formula:
% biodegradation = (BOD (mg O2/mg chemical))/ (ThODNH4 or NO3(mg chemical)) * 100 %
Where:
BOD = Biochemical oxygen demand of the test or reference item
= (mg O2uptake/L by test and/or reference item) – (mg O2 uptake/L by inoculum control) / (mg test and/ or reference item per liter)
ThODNH4 or NO3= Theoretical oxygen demand of the test or reference item without or with nitrification
Table 2: Biodegradation of Oxypicoline RF and the reference item
Time (days) | Percentage Biodegradation* | |||||||
Test item based on | Procedure control based on | Toxicity control based on | ||||||
ThOD NH4 | ThOD NO3 | ThOD | ThOD NH4 | ThOD NO3 | ||||
Flask No. | Flask No. | Flask No. | Flask No. | |||||
5 | 6 | 5 | 6 | 3 | 4 | 7 | ||
Mean (Day 28) | 3 | 3 | 93 | not applicable |
*corrected for the inoculum controls
Test substance is not inhibitory at tested concentration.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: not readily biodegradable
- Conclusions:
- The percent biodegradation of the test item was calculated based on the theoretical oxygen demand of 2.31 mg O2/mg test item without nitrification (ThOD(NH4) and 2.54 mg O2/mg test item with nitrification (ThOD(NO3). Consequently, Oxypicoline RF was found to be not biodegradable under the test conditions within 28 days.
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