Registration Dossier
Registration Dossier
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EC number: 216-378-7 | CAS number: 1569-69-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Cyclohexylmercaptan has been tested for mutagenicity in a reliable study conducted according to OECD 471 and in compliance with GLP (Verspeek-Rip, 2013). No increase in the number of revertant colonies was observed when the substance was tested up to cytotoxic concentrations in Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA1537 and Escherichia coli WP2 uvrA, in the presence and absence of metabolic activation. The study was conducted using the pre-incubation method, and was repeated to confirm the negative result. Appropriate positive and solvent controls were included and gave expected results. It is concluded that the test substance is negative for mutagenicity to bacteria under the conditions of the test.
Justification for selection of genetic toxicity endpoint
The selected bacterial mutagenicity study was the only available reliable information for the registered substance. It was conducted according to an appropriate OECD guideline and in compliance with GLP.
Short description of key information:
In vitro
Bacterial mutagenicity: negative with and without metabolic activation in Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA1537 and Escherichia coli WP2 uvrA (OECD 471) (Verspeek-Rip, 2013).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available in vitro bacterial mutagenicity data, cyclohexylmercaptan is not classified for mutagenicity according to Regulation (EC) No1272/2008.
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