Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 412-720-6 | CAS number: 156653-67-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 April 1993 to 15 April 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to EU & OECD test guidance in compliance to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- 84/449/EEC
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Details on test material:
- See below
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test Species: Wistar rat
Strain: HOE: WISKF (SPF71)
Source: HOECHST AG, Kastengrund, SPF breeding colony
Body Weight at start of study: Males: x = 180g (=100%)
s = ± 4g
x min = 175g (-2.8%)
x max = 186g (+3.3%)
n = 5
Females: x = 177g (=100%)
s = ±3g
x min = 173g (-2.3%)
x max = 181g (+2.3%)
n = 5
Age at start of study: Males: approx 7 weeks
Females: approx 8 weeks
Randomisation: Randomisation schemes 404/92 and 617/92
Animal Maintenance: In fully air-conditioned rooms in Makrolon cages (Type 4) on soft wood granulate in groups of 5 animals
Room Temperature: 22 ±3⁰C
Relative Humidity: 55 ±20%
Lighting time: 12 hours daily
Acclimatisation: not necessary (breeding at extensive identical conditions)
Withdrawal of food: from about 16 hours before to 3- 4 hours after treatment
Food: Altromin 1324 rat diet (Altromin GmbH, Lage/Lippe), ad libitum
Water: tap water in plastic bottles, ad libitum
Animal identification: fur-marking with KMnO4 and cage numbering
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- deionised
- Details on oral exposure:
- The prepared test substance was administered by gavage to fasted animals at the stated dosage.
- Doses:
- 2000mg/kg body weight
- No. of animals per sex per dose:
- Males 5, Females 5
- Control animals:
- no
- Details on study design:
- Test Groups
The acute oral toxicity of Reaktiv-Gelb F-66 923 FW was tested only at a dose level of 2000 mg/kg body weight.
Five male and five female rats received the test compound as a 20% solution, the application volume being 10 ml/kg bodyweight.
If no compound-related mortality is produced in this limit test according to the guidelines no full study has to be carried out.
Preparation of the test substance
Reaktiv-Gelb F-66 923 FW was dissolved in the stated concentration in deionised water and distributed homogeneously by means of a magnetic stirrer.
Stability and homogeneity of the test substance was determined by analytical methods.
Test procedure
The prepared test substance was administered by gavage to fasted animals at the stated dosage. The observation period following treatment lasted for 14 days. Symptoms were recorded twice every day (in the morning and in the afternoon), on weekends and holidays only once. During this time the animals were weighed weekly. At the end of the observation period the animals were killed by carbon dioxide asphyxiation, dissected and examined for macroscopically visible changes.
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred during the whole study.
- Clinical signs:
- other: The following clinical signs were observed after the application of Reaktiv-Gelb F-66 923 FW: squatting posture, stilted gait as well as mucous and yellow discoloured feces. From the first day p.a. up to the end of the study the animals were free of sympt
- Gross pathology:
- The animals killed at the end of the observation period showed no macroscopically visible changes.
- Other findings:
- None detailed
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acute oral toxicity testing of Reaktiv-Gelb F-66 923 FW in the Wistar rat yielded a median lethal dose above 2000 mg/kg b.w. in both male and female animals.
- Executive summary:
Study conducted to EU test guidance 84/449/EEC part B1 and OECD test guideline 401 in compliance with GLP.
Acute oral toxicity testing of Reaktiv-Gelb F-66 923 FW in the Wistar rat yielded a median lethal dose above 2000 mg/kg b.w. in both male and female animals.
After application of 2000 mg/kg b.w. no deaths occurred.
Clinical signs were observed after application of 2000 mg/kg b.w., consisting of squatting posture and stilted gait. The feces of three animals were mucous and discoloured yellow.
From the first day p.a. up to the end of the study the animals were free of symptoms .
Development of body weight was not impaired.
The animals killed at the end of the observation period showed no macroscopically visible changes.
The substance is not considered harmful.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Bár az ECHA sok anyagot az ön nyelvén is rendelkezésre bocsát az interneten, az oldal egy része csak angolul érhető el. Bővebben az ECHA többnyelvűségre irányuló gyakorlatáról.
Üdvözöljük az ECHA weboldalán! Az oldal az Internet Explorer 7 (és korábbi verziók) alatt nem teljes mértékben támogatott. Kérjük, frissítse Internet Explorer böngészőjét egy újabb verzióra!
Ez a weboldal cookie-kat használ a legjobb felhasználói élmény biztosítása érdekében.
További információ a cookie-k használatáról.