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EC number: 273-110-1 | CAS number: 68938-03-4 The complex combination of hydrocarbons produced by the distillation of products from the hydrogenation of isononanal. It consists predominantly of C6 olefins and paraffins and C9 alcohols and aldehydes and boiling in the range of approximately 110°C to 202°C (230°F to 396°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Remarks:
- The study has been conducted according to guideline OECD TG 405.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- between 26 August 2008 and 04 September 2008.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection: 21/08/2007 Date of signature: 15/10/07
Test material
- Reference substance name:
- Octene, hydroformylation products, low-boiling
- EC Number:
- 273-110-1
- EC Name:
- Octene, hydroformylation products, low-boiling
- Cas Number:
- 68938-03-4
- IUPAC Name:
- Octene, hydroformylation products, low-boiling
- Details on test material:
- - Name of test material: Oxooil LS9
- Physical state: clear colourless liquid
- Storage condition of test material: room temperature in the dark
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source:
Harlan UK Limited, Bicester, Oxon, UK
- Age at study initiation:
twelve to twenty weeks old
- Weight at study initiation:
At the start of the study the animals were in the weight range of 2.0 to 3.5 kg
- Housing:
The animals were individually housed in suspended cages
- Diet (e.g. ad libitum):
Free access to food (2030 Teklad Global Rabbit diet supplied by Harlan Teklad, Blackthorn, Bicester, Oxon, UK) was allowed throughout the study
- Water (e.g. ad libitum):
Free access to mains drinking water was allowed throughout the study
- Acclimation period:
at least five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
The temperature awas set to achieve limits of 17 to 23°C
- Humidity (%):
The relative humidity was set to achieve limits of 30 to 70%
- Air changes (per hr):
The rate of air exchange was at least fifteen changes per hour
- Photoperiod (hrs dark / hrs light):
the lighting was controlled by a time switch to give twelve hours continuous light (06:00 to 18:00) and twelve hours darkness
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The left eye remained untreated and was used for control purposes.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):
A volume of 0.1 ml of the test material
- Concentration (if solution):
For the purpose of the study the test material was used as supplied.
VEHICLE
Not applicable - Duration of treatment / exposure:
- Assessment of ocular damage/irritation was made approximately 1 hour and 24, 48 and 72 hours
- Observation period (in vivo):
- Not applicable
- Number of animals or in vitro replicates:
- Initially, a single rabbit was treated
After consideration of the ocular responses produced in the first treated animal, two additional animals were treated. - Details on study design:
- REMOVAL OF TEST SUBSTANCE
Not applicable
SCORING SYSTEM:
The numerical values corresponding to each animal, tissue and observation time were recorded. The data relating to the conjunctivae were designated by the letters A (redness), B (chemosis) and C (discharge), those relating to the iris designated by the letter D and those relating to the cornea by the letters E (degree of opacity) and F (area of cornea involved). For each tissue the score was calculated as follows:
Score for conjunctivae = (A + B + C) x 2
Score for iris = D x 5
Score for cornea = (E x F) x 5
Using the numerical data obtained a modified version of the system described by Kay J H and Calandra J C (1962), J. Soc. Cosmet. Chem. 13, 281 289 (see Appendix 3) was used to classify the ocular irritancy potential of the test material. This was achieved by adding together the scores for the cornea, iris and conjunctivae for each time point for each rabbit. The group means of the total scores for each observation were calculated. The highest of these group means (the maximum group mean score) together with the persistence of the reactions enabled classification of the eye irritancy potential of the test material.
If evidence of irreversible ocular damage is noted, the test material will be classified as corrosive to the eye.
TOOL USED TO ASSESS SCORE:
Examination of the eye was facilitated by the use of the light source from a standard ophthalmoscope
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 67702 Male
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: No effects observed
- Remarks on result:
- other: Initial pain reaction = 2
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 67719 Male
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: No effects observed
- Remarks on result:
- other: Initial pain reaction = 2
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 67720 Male
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: No effects observed
- Remarks on result:
- other: Initial pain reaction = 2
- Irritation parameter:
- iris score
- Basis:
- animal: 67702 Male
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: No effects observed
- Remarks on result:
- other: Initial pain reaction = 2
- Irritation parameter:
- iris score
- Basis:
- animal: 67719 Male
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: No effects observed
- Remarks on result:
- other: Initial pain reaction = 2
- Irritation parameter:
- iris score
- Basis:
- animal: 67720 Male
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: No effects observed
- Remarks on result:
- other: Initial pain reaction = 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 67702 Male
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: Initial pain reaction = 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 67719 Male
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: Initial pain reaction = 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 67720 Male
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48hours
- Remarks on result:
- other: Initial pain reaction = 2
- Irritation parameter:
- chemosis score
- Basis:
- animal: 67702 Male
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Initial pain reaction = 2
- Irritation parameter:
- chemosis score
- Basis:
- animal: 67719 Male
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Initial pain reaction = 2
- Irritation parameter:
- chemosis score
- Basis:
- animal: 67720 Male
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Initial pain reaction = 2
- Irritant / corrosive response data:
- Ocular Reactions
Individual and group mean scores for ocular irritation are given in Table 1 and Table 2.
No corneal or iridial effects were noted during the study.
Moderate conjunctival irritation was noted in all treated eyes one hour after treatment with minimal conjunctival irritation noted at the 24-hour observation.
All treated eyes appeared normal at the 48-hour observation. - Other effects:
- Individual bodyweights and bodyweight changes are given in Table 3.
Two animals showed expected gain in bodyweight during the study while the remaining animal showed no gain in bodyweight.
Any other information on results incl. tables
Table1 IndividualScores and Individual Total Scoresfor Ocular Irritation
Rabbit Number and Sex |
67702Male |
67719Male |
67720Male |
|||||||||
IPR= 2 |
IPR = 2 |
IPR = 2 |
||||||||||
Time After Treatment |
1 Hour |
24 Hours |
48 Hours |
72 Hours |
1 Hour |
24 Hours |
48 Hours |
72 Hours |
1 Hour |
24 Hours |
48 Hours |
72 Hours |
CORNEA |
|
|
|
|
|
|
|
|
|
|
|
|
E = Degree of Opacity |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
F = Area of Cornea Involved |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Score (E x F) x 5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
IRIS |
|
|
|
|
|
|
|
|
|
|
|
|
D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Score (D x 5) |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
CONJUNCTIVAE |
|
|
|
|
|
|
|
|
|
|
|
|
A = Redness |
2 |
1 |
0 |
0 |
2 |
1 |
0 |
0 |
2 |
1 |
0 |
0 |
B = Chemosis |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
C = Discharge |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
Score (A + B + C) x 2 |
8 |
2 |
0 |
0 |
8 |
2 |
0 |
0 |
8 |
2 |
0 |
0 |
Total Score |
8 |
2 |
0 |
0 |
8 |
2 |
0 |
0 |
8 |
2 |
0 |
0 |
Table2 Individual Total Scores and Group Mean Scoresfor Ocular Irritation
Rabbit Number and Sex |
Individual Total Scores At: |
|||
1 Hour |
24 Hours |
48 Hours |
72 Hours |
|
67702Male |
8 |
2 |
0 |
0 |
67719Male |
8 |
2 |
0 |
0 |
67720Male |
8 |
2 |
0 |
0 |
Group Total |
24 |
6 |
0 |
0 |
Group Mean Score |
8.0 |
2.0 |
0.0 |
0.0 |
Table3 Individual Bodyweights and Bodyweight Change
Rabbit Number |
Individual Bodyweight (kg) |
Bodyweight Change (kg) |
|
Day 0 |
Day 14 |
||
67702Male |
3.05 |
3.09 |
0.04 |
67719Male |
2.67 |
2.67 |
0.00 |
67720Male |
2.63 |
2.68 |
0.05 |
IPR= Initial pain reaction
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Slightly irritating and all recorded effects reversible within 48 hours. Not classified.
- Executive summary:
Introduction. The study was performed to assess the irritancy potential of the test material to the eye of the New Zealand White rabbit. The method was designed to meet the requirements of the following:
* OECD Guidelines for the Testing of Chemicals No. 405 “Acute Eye Irritation/Corrosion” (adopted)Method B5 Acute
* Toxicity (Eye Irritation) of Commission Directive 2004/73/EC
Result. A single application of the test material to the non-irrigated eye of three rabbits produced moderate conjunctival irritation. All treated eyes appeared normal at the 48-hour observation.
Conclusion. The test material produced a maximum group mean score of 8.0 and was classified as a minimal irritant (Class 3 on a 1 to 8 scale) to the rabbit eye according to a modified Kay and Calandra classification system.
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