Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-718-2 | CAS number: 1474044-80-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 1 - July 10, 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Follows standard procedures accepted at the time of the study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FHSLA CFR 21 191.11
- Deviations:
- not specified
- GLP compliance:
- no
- Remarks:
- conducted prior to GLP regulations
Test material
- Reference substance name:
- barium bis(di C8-C10, branched, C9 rich, alkylnaphthalenesulphonate)
- EC Number:
- 939-718-2
- Cas Number:
- 1474044-80-8
- Molecular formula:
- C28H44O3S.1/2Ba
- IUPAC Name:
- barium bis(di C8-C10, branched, C9 rich, alkylnaphthalenesulphonate)
- Test material form:
- other: as solution in light paraffinic and naphthenic petroleum distillates
- Details on test material:
- Brown viscous liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: The rabbits were prepared by clipping the skin of the trunk free of hair. Epidermal abrasions were made over a 2-3 cm2 area on each rabbit. The patches were secured with tape and covered with a plastic trunk band to prevent evaporation.
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 and 72 hours
- Number of animals:
- Six New Zealand Albino Rabbits, 2-3- 3.0 kg.
- Details on study design:
- The rabbits were prepared by clipping the skin of the trunk free of hair. Epidermal abrasions were made over a 2-3 cm2
area on each rabbit. Two, 2.5 cm2 gauze patches were placed on each rabbit. One patch was placed over the intact skin, the
second patch over the abraded skin. Fivetenths of a mil I il iter of test material was placed under each patch. The patches were
secured with tape and covered with a plastic trunk band to prevent evaporation. The rabbits were immobilized in head stocks for
24 hours at which time the patches were removed and the rabbits returned to their cages.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- >= 2.3
- Max. score:
- 8
- Reversibility:
- no data
- Irritant / corrosive response data:
- See table below
- Other effects:
- No adverse effects reported.
Any other information on results incl. tables
Erythema and Eschar Formation |
Exposure Time hours |
Average Exposure Unit Value |
Intact Skin |
24 |
2.8 |
Do |
72 |
1.7 |
Abraded Skin |
24 |
3.0 |
Do |
72 |
1.7 |
Edema Formation |
Subtotal |
9.2 |
Intact Skin |
24 |
0 |
Do |
72 |
0 |
Abraded Skin |
24 |
0 |
Do |
72 |
0 |
|
Subtotal |
0 |
|
Total |
9.2 |
|
Primarl Irritation Score (Index)
|
2.3 |
The test material is a moderate primary skin irritant
Observations: No untoward reactions.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test material is a moderate primary skin irritant.
- Executive summary:
Primary Skin Irritation (FHSLA, CFR Title 21, para. 191. 11) was conducted in rabbits with the test substance. Intact and abraded skin were evaluated. 0.5 ml of test material was applied and the treatment period was 24 hours.
Skin lesions were evaluated at 24 and 72 hours and scored in accordance with CFR Title 21, para. 191.11 and evaluated as follows:
Score
0.5 non-primary irritant.
0.6- 2.0 mild primary irritant.
2.1 - 5.0 moderate primary irritant.
6.0 or > severe primary irritant.
The primary irritation index was 2.3 indicating the the test material is a moderate primary skin irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.