Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 224-518-3 | CAS number: 4394-85-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, irrelevant route of exposure
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The LD50 after intraperitoneal injection of the test substance into mice was determined.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 4-morpholinecarbaldehyde
- EC Number:
- 224-518-3
- EC Name:
- 4-morpholinecarbaldehyde
- Cas Number:
- 4394-85-8
- Molecular formula:
- C5H9NO2
- IUPAC Name:
- morpholine-4-carbaldehyde
- Details on test material:
- - Name of test material (as cited in study report): N-Formylmorpholin
- Physical state: liquid
- Analytical purity: 99.6 %
- pH: neutral
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Kisslegg
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 25-32 g; females: 18-26 g
- no further data
ENVIRONMENTAL CONDITIONS
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Remarks:
- with Traganth
- Details on exposure:
- - single i.p. injection
- concentration in vehicle: 20 or 30 % v/v
- Amount of vehicle: 5.0 or 6.25 mL/kg bw of the 30 % test item solution and 8.33, 10.66, 13.33, 16.66 and 21.4 mL/kg bw of the 30 % test item solution - Doses:
- 1150, 1437.5, 2875, 3680, 4600, 5750, 7360 mg/kg bw (under consideration of absolute density)
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 025 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: reported as > 3.5 mL/kg bw
- Mortality:
- - No deaths occurred up to a dose of 2875 mg/kg bw.
- At 3680 mg/kg bw 3/10 animals (2/5 males and 1/5 females) died within 7 days.
- At 4600 mg/kg bw 6/10 animals (2/5 males and 4/5 females) died, 5 of them within 24 hours.
- At 5750 and 7360 mg/kg bw all male and female mice (10/10 each) died within 2-3 hours. - Clinical signs:
- Clinical signs observed included: panting and dyspnea, saltatory and rolling convulsions, prone position, apathy, salivation and bristling coat.
- Body weight:
- no data
- Gross pathology:
- In some animals adhesions in the abdominal cavity were observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.