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Diss Factsheets
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EC number: 417-040-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
The methods employed in this study were similar to those described in 40 CFR Part 798 , EPA Health Effects Testing Guidelines - Subpart B - General Toxicity Testing, September 1985. Coagulant 122 (solid) when administered as supplied to 5 male and 5 female
albino rats, appears to have an acute oral LD50 greater than 5.0 g/kg.
Acute toxicity: inhalation
No data available due exposure by inhalation being unlikely. Two reliable studies are available (oral and dermal)
Acute dermal toxicity:
A study was performed to assess the acute dermal toxiciry of Coagulant 122 (solid) to the rat. The method followed was that described in EEC Methods for the determination of toxiciry, Annex to Directive 92/69/EEC (OJ No. L3834, 29.12.92), Part B, Method 8.3. A The acute lethal dermal dose to rats of Coagulant 122 (solid) was found to be greater than 2.0 g/kg bodyweight.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 500 mg/kg bw
- Quality of whole database:
- Klimish: 1
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- n/a
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Klimish: 1
Additional information
Acute Oral Toxicity:
OBSERVATIONS
Males: All animals appeared normal throughout the 14 -day observation period.
Females: All animals appeared normal throughout the 14day observation period.
GROSS PATHOLOGY
Males: no gross abnormalities were observed for the animals necropsied at the conclusion of the 14 -day observation period.
Females: no gross abnormalities were observed for the animals necropsied at the conclusion of the 14 -day observasion period.
Acute Dermal Toxicity:
MORTALITY
There were no deaths following a single dermal application of Coagulant 122 (solid) to a group of ten rats (five males and five females) as a dosage of 2.0 g/kg bodywlight.
CLINICAL SIGNS
There were no signs of systemic reaction to treatment.
DERMAL RESPONSES
Sites of application of Coagulant 122 (solid) showed no irritation or other dermal changes (scores of zero for erythema and oedema were record 1 for all animals).
BODYWEIGHT
Slightly low bodyweight gains were recorded for three males and four females on Day 8, with a similar trend noted for three males and one female on Day 15. All other rats achieved a satisfactory bodyweight gain throughout the study.
MACROSCOPIC EXAMINATION
No macroscopic abnormalities were observed for animals killed on Day 15.
Justification for selection of acute toxicity – oral endpoint
Two reliable studies available
Justification for selection of acute toxicity – inhalation endpoint
Exposure by inhalation being unlikely.
Two reliable studies available for acute oral and dermal toxicity.
Justification for selection of acute toxicity – dermal endpoint
Two reliable studies available
Justification for classification or non-classification
Acute Toxicity (Oral):
The substance tested was a ~50% solution of Coagulant 122
(solid). The LD50 value for this 50% solution was >5000
mg/kg which theoretically represents a >2500 mg/kg value for
the Coagulant 122 (solid).
Acute Toxicity (Dermal):
The acute lethal dermal dose to rats of Coagulant 122 (solid) was found to be >2000 mg/kg bodyweight
Acute Toxicity (Inhalation):
Exposure by inhalation being unlikely
Based on test results: Coagulant 122 (solid) will not require labelling with H302 cat. 4: Harmful if swallowed; H312 category 4:Harmful in contact with skin", in accordance with Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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