6,10-dimethylundeca-3,5,9-trien-2-one

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions

Data source

Reference

Reference 1

Reference Type:

other company data

Title:

Unnamed

Year:

1988

Report date:

1988

Reference 2

Reference Type:

secondary source

Title:

No information

Author:

BASF AG

Year:

2000

Bibliographic source:

ECB IUCLID dataset

Report date:

2000

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

BASF AG internal method which was in large part equivalent to OECD Guideline401

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

6,10-dimethylundeca-3,5,9-trien-2-one

EC Number:

205-457-1

EC Name:

6,10-dimethylundeca-3,5,9-trien-2-one

Cas Number:

141-10-6

Molecular formula:

C13H20O

IUPAC Name:

6,10-dimethylundeca-3,5,9-trien-2-one

Details on test material:

- Name of test material (as cited in study report): Pseudojonon
- Lot/batch No.: 88/609

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Dr. K. Thomae GmbH, D-7950 Biberach, Germany
- Weight at study initiation: mean weights: male 189 g; female 180 g
- Fasting period before study: 16 h, but water was available ad libitum
- Animal identification: cage cards
- Housing: 5 animals per cage; stainless steel wire mesh cages, type DK-III (Becker & Co., Castrop-Rauxel, Germany)
- Diet (e.g. ad libitum): ad libitum, Kliba-Labordiaet 343, Klingentalmuehle AG, CH-4303 Kaiseraugst, Switzerland
- Water (e.g. ad libitum): ad libitum, tap water
- Acclimation period: at least one week


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 / 12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Details on oral exposure:

VEHICLE
- 0.5% aquous carboxymethyl cellulose emulsion
- Concentration in vehicle: 20 g/100 ml
- Amount of vehicle (if gavage): 10 ml/kg bw
- Justification for choice of vehicle: aquous formulation corresponds to the physiological medium

OTHER
- time of administration: in the morning

Doses:

2000 mg/kg

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: recording of signs of symptoms several times on day of administration; at least once each workday. Check for moribund and dead animals twice each workday and once on holidays
- Necropsy of survivors performed: yes; withdrawal of food about 16 h before sscrifice with CO2; gross-pathological examination
- Other examinations performed: body weight, befor administration and after 7 and 13 days

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

0/10

Clinical signs:

other: no clinical signs noted

Gross pathology:

no pathological findings noted

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU