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EC number: 236-852-7 | CAS number: 13515-40-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Nanomaterial dustiness
Administrative data
- Endpoint:
- nanomaterial dustiness
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 Jul 2020 - 16 Sep 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Remarks:
- According to DIN EN 17199-3
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DIN EN 17199-3
- Version / remarks:
- DIN EN 17199-3:2019-12 “Workplace exposure - Measurement of dustiness of bulk materials that contain or release respirable NOAA or other respirable particles - Part 3: Continuous drop method
- Deviations:
- yes
- Remarks:
- 1 measurement performed
- GLP compliance:
- no
- Type of method:
- continuous drop
- Sampling:
- The test material was used without further treatment (e.g. drying). The relative humidity of the test atmosphere was 51%. 59.4 g (259.4 cm³) test material was used for the measurement, at a dosing rate of 5.94 g/min. 1 measurement was performed for background and sample, with a measurement duration of 3 and 10 minutes, respecitvely.
Test material
- Reference substance name:
- 2-[(4-chloro-2-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutyramide
- EC Number:
- 236-852-7
- EC Name:
- 2-[(4-chloro-2-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutyramide
- Cas Number:
- 13515-40-7
- Molecular formula:
- C17H15ClN4O5
- IUPAC Name:
- 2-[(4-chloro-2-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxobutanamide
- Test material form:
- solid: nanoform, no surface treatment
Constituent 1
Results and discussion
Dustiness indexopen allclose all
- Key result
- Mean:
- 37 366 other: particles/mg
- Remarks on result:
- other: dustiness index as number of airborne particles per mg in the nanoscale (10 nm - 100 nm)
- Mean:
- 4 188 other: particles/cm³
- Remarks on result:
- other: number of airborne nanoparticles per cm³, size range 10-100 nm
Any other information on results incl. tables
The cleaned, almost particle-free air had a total particle count of 6 particles/cm³ in the range of 10 nm – 417 nm, whereby the nanoscale fraction (10 - 100 nm) contained 4 particles/cm³.
Summary SMPS result:
Range [nm] | Mean [nm]
|
Concentration [ particles /cm³] | I(CD) [particles/mg]
| E(CD) [1/mg·s] |
10 -100 | 73.1 | 4187.8 | 37365.8 | 62.3 |
100 - 417 | 186.7 | 16277.7 | 145238.4 | 242.1 |
10 - 417 | 163.5 | 20465.4 | 182604.2 | 304.3 |
Summary OPS result:
Range [µm] | Mean [µm]
|
Concentration [ particles /cm³] | I(CD) [particles/mg]
| E(CD) [1/mg·s] |
0.3 - 10 | 5.6 | 95.7 | 854.2 | 1.4 |
ICD: dustiness index as number of airborne particles per mg
ECD: emission rate as number of particles per mg per second
mean: average particle diameter in nm
N: number of airborne particles
Applicant's summary and conclusion
- Executive summary:
The dusting behaviour of the test material was investigated using DIN EN 17199-3:2019-12 "workplace exposure - measurement of dustiness of bulk materials that contain or release respirable nano objects and their aggregates and agglomerates or other respirable particles- Part 3: Continuous drop method".
The dust released by the falling test material was measured by a scanning mobility particle sizer (SMPS, 10 - 417 nm) and an optical particle sizer (3 - 10 µm). The counterflow was provided by clean, almost particle-free air.
The SMPS counted 4188 particles in the nanoscale (10 - 100 nm) per cm³, corresponding to a dustiness index of 37366 particles in the nanoscale (10 - 100 nm) per mg. The particle number in the whole SMPS size range (10-417 nm) was 16278 per cm³, corresponding to a dustiness index of 145238 particles/mg (size 10 - 417 nm).
The mean size of the nanoparticles was 73.1 nm, the mean size of particles in the range 10 - 417 nm was 186.7.
The OPS (0.3 - 10 µm) counted 95.7 particles per cm³ corresponding to a dustiness index of 854 particles per mg. The mean size of the particles was 5.6 µm.
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