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Diss Factsheets
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EC number: 208-797-9 | CAS number: 542-05-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based upon the predicted data and avaliable data from authoritative database, for the target chemical (3-oxoglutaric acid) as well as its read across glutaric acid, it can be concluded that in the concentration ranges that are mentioned in the respective end points and also the waivers (given the exposure considerations), the chemicals belonging to the same category of di-carboxylic acid are unlikely to exhibit repeated dose toxicity by the oral, inhalation and dermal route.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The target chemical 3-oxoglutaric acid and the read across chemical belong to the same category; that of “dicarboxylic acid”. Both the chemicals share physico-chemical properties within an acceptable range as well as environmental fate properties and aquatic toxicity properties thereby qualifying for suitable read-across. In general, the most striking pattern across the two chemicals is their low toxicity profile.
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS database
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 90 D
- Frequency of treatment:
- intermittent
- Remarks:
- Doses / Concentrations:
135 gm/kg
Basis:
no data - Dose descriptor:
- other: TDLo - Lowest published toxic dose
- Effect level:
- 135 other: gm/kg/90D (intermittent)
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Nutritional and Gross Metabolic - weight loss or decreased weight gain
- Critical effects observed:
- not specified
- Conclusions:
- Repeated dose toxicity (TDLo - Lowest published toxic dose ) via oral route was examined in rat at dose concentration of 135 gm/kg/90D (intermittent). Thus, it can be concluded that glutaric acid shall not exhibit repeated dose toxicity via the oral route below the concentration mentioned in the end point.
- Executive summary:
Repeated dose toxicity (TDLo - Lowest published toxic dose ) via oral route was examined in rat at dose concentration of 135 gm/kg/90D (intermittent). Thus, it can be conlcuded that glutaric acid shall not exhibit repeated dose toxicity via the oral route below the concentration mentioned in the end point.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- chronic
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: inhalation
- Data waiving:
- exposure considerations
- Justification for data waiving:
- other:
- Critical effects observed:
- not specified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Repeated dose toxicity: dermal - systemic effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 21-28 days
- No. of animals per sex per dose:
- unspecified
- Dose descriptor:
- NOAEL
- Effect level:
- 671.75 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- not specified
- Critical effects observed:
- not specified
- Conclusions:
- Repeated dose toxicity NOAEL (No observed adverse effect level) of 3-oxoglutaric acid to rabbit by the dermal route was estimated at a dose concentration of 671.75 mg/kg bw/day.On the basis of this NOAEL value it is concluded that the test substance is not toxic to rabbit by the dermal route below the above mentioned dose.
- Executive summary:
Repeated dose toxicity NOAEL (No observed adverse effect level) of 3-oxoglutaric acid to rabbit by the dermal route was estimated at a dose concentration of 671.75 mg/kg bw/day.On the basis of this NOAEL value it is concluded that the test substance is not toxic to rabbit by the dermal route below the above mentioned dose.
In the absence of experimental data for the repeated dose toxicity, the predicted value is considered to be reliable pointer of the low toxicity potential of 3 -oxoglutaric acid. This is also supported by data available in certain literature which indiacte dicarboxylic acid to exhibit low toxicity.
Reference
The prediction was based on dataset comprised from the following descriptors: NOAEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and ("b" and ( not "c") ) ) and ("d" and "e" ) )
Domain logical expression index: "a"
Similarity boundary:Target: C(=O)(O)CC(=O)CC(=O)O
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as No alert found by Protein binding by OASIS v1.1
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Schiff base formation OR Schiff base formation >> Nucleophilic cycloaddition to diketones OR Schiff base formation >> Nucleophilic cycloaddition to diketones >> Diketones by Protein binding by OASIS v1.1
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is >= -3.81
Domain logical expression index: "e"
Parametric boundary:The target chemical should have a value of log Kow which is <= -0.687
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 671.75 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rabbit
- Quality of whole database:
- In the absence of experimental data for the repeated dose toxicity by the dermal route, the predicted value is considered to be reliable pointer of the low toxicity potential of 3 -oxoglutaric acid. This is also supported by data available in certain literature which indicate dicarboxylic acid to exhibit low toxicity.
Additional information
Based upon the predicted data and avaliable data from authoritative database, for the target chemical (3-oxoglutaric acid) as well as its read across glutaric acid, it can be concluded that in the concentration ranges that are mentioned in the respective end points and also the waivers (given the exposure considerations), the chemicals belonging to the same category of di-carboxylic acid are unlikely to exhibit repeated dose toxicity by the oral, inhalation and dermal route.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
Data is from an authoritative database. TDLo - (Lowest published toxic dose ) via oral route was examined in rat at dose concentration of 135 gm/kg/90D (intermittent)
Justification for selection of repeated dose toxicity dermal - systemic effects endpoint:
Model considered relaible by OECD
Justification for classification or non-classification
Based upon the predicted data and avaliable data from authoritative database, for the target chemical (3-oxoglutaric acid) as well as its read across glutaric acid, it can be concluded that in the concentration ranges that are mentioned in the respective end points and also the waivers (given the exposure considerations), the chemicals belonging to the same category of di-carboxylic acid are unlikely to exhibit repeated dose toxicity by the oral, inhalation and dermal route.
Thus, the chemical 3 -oxoglutaric acid is not classified as exhibiting repeated dose toxicity.
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