Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 266-104-5 | CAS number: 66069-34-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This information is from a document which summarises many investigations on the substance potassium clavulanate, the document reviews the results of many study reports and very little information regarding the methods has been included, which is why a klimisch reliability of 4 has been given.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Potassium Clavulanate
- IUPAC Name:
- Potassium Clavulanate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- dog
- Strain:
- Beagle
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- not stated
- Post exposure period:
- not stated
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50, 250, 400, 500 mg/kg
Basis:
nominal conc.
- No. of animals per sex per dose:
- no data available
- Control animals:
- no
Examinations
- Examinations:
- blood pressure, heartrate were assessed during the study
Results and discussion
Any other information on results incl. tables
Cardiovascular toxicity has been assessed in the anaesthetised beagle dog. A small persistent
fall in blood pressure occurred at the top dosage, with maximal plasma concentrations of 1675 and 1470 micro.g/ml.
Increase In heart rate occurred at Intermediate dose levels. Slight depression of T-waves was seen on infusion of 50 mg/kg (plasma concentrations of BRL.14151 86 and 56 micro.g/ml) and increased to T-wave inversion after a cumulative dose of 400 mg/kg. In a further study in unanaesthetised rats, reversible T-wave changes were observed after 250 mg/kg dosed intravenously, but did not regress after 500 mg/kg intravenously.
Applicant's summary and conclusion
- Conclusions:
- A small persistent fall in blood pressure occurred at the top dosage, with maximal plasma concentrations of 1675 and 1470 micro.g/ml. Increase In heart rate occurred at Intermediate dose levels.
- Executive summary:
Cardiovascular toxicity has been assessed in the anaesthetised beagle dog. A small persistent fall in blood pressure occurred at the top dosage, with maximal plasma concentrations of 1675 and 1470 micro.g/ml. Increase In heart rate occurred at Intermediate dose levels.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.