Registration Dossier
Registration Dossier
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EC number: 270-147-5 | CAS number: 68411-76-7 The residuum from the distillation of the products from the air oxidation of cyclohexane. It consists of alcohols, acids and lactones having carbon numbers predominantly in the range of C4 through C6.
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US Federal Hazardous Substances Act, 16 CFR 1500.42 as amended January 1, 1975
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclohexane, oxidized, non-volatile residue
- EC Number:
- 270-147-5
- EC Name:
- Cyclohexane, oxidized, non-volatile residue
- Cas Number:
- 68411-76-7
- Molecular formula:
- contains many components
- IUPAC Name:
- 5-hydroxypentanoic acid; 6-hydroxyhexanoic acid; hexanedioic acid; oxolan-2-one; pentanoic acid
- Reference substance name:
- Cyclohexane oxidized, non-volatile residue
- IUPAC Name:
- Cyclohexane oxidized, non-volatile residue
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- 72 h
- Observation period (in vivo):
- after 1,2,3 and 16 days
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- other: 24-48-2 h
- Score:
- 3.6
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- after 16 days: 3 x opalescent cornea, 1x ruptured cornea
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- other: 24-48-72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not reversible
- Remarks:
- after 16 days: 1 ruptured cornea
- Remarks on result:
- other: iris of one animal could not be observed due to opacity of cornea
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- other: 24 -48 - 72 h
- Score:
- 1.9
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- other: 24-48-72 h
- Score:
- 2.4
- Max. score:
- 3
- Reversibility:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Migrated information
- Executive summary:
The substance is a severe eye irritant and must be classified as CLP cat 1, H318 and for DSD with R41.
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