Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 262-062-7 | CAS number: 60113-43-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Genetic toxicity in vitro:
3-Formylpinan was tested for its mutagenic potential based on the ability to induce point mutations in selected loci of several bacterial strains, i .e . Salmonella typhimurium and Escherichia coli, in a reverse mutation assay (BASF AG, 2001). The study was performed according to OECD guideline 471 in compliance with GLP using S. typhimurium strains TA 1535, TA 100, TA 1537, TA 98 and E. coli strain WP2 uvrA in a dose range of 15,625 µg - 5000 µg/plate in the standard plate test (SPT) or 7.50 µg - 120 µg/plate in the preincubation test (PIT), respectively. Under both test conditions the substance was tested with and without metabolic activation (Aroclor-induced rat liver S-9 mix).
No precipitation of the test substance was found. A bacteriotoxic effect (reduced background growth, decrease in the number of revertants, reduction in the titer) was observed in the standard plate test depending on the strain and test conditions from about 125 µg - 250 µg/plate onward. In the preincubation assay bacteriotoxicity was observed depending on the strain and test conditions from about 30 µg - 60 µg/plate onward.
An increase in the number of his+or trp+revertants was not observed in the standard plate test or in the preincubation test either without S-9 mix or after the addition of a metabolizing system.
Conclusion: The test substance was not mutagenic in the Salmonella typhimurium/Escherichia coli reverse mutation assay under the experimental conditions chosen.
Short description of key information:
Ames test with and without metabolic activation: negative (BASF AG, 2001)
Endpoint Conclusion:
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
