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Diss Factsheets
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EC number: 905-983-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no guideline defined, but available information is sufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Über das Verhalten des Organismus bei Einwirkung verschiedener Weichmacher
- Author:
- Bornmann G, Loeser A, Mikulicz K, Ritter K
- Year:
- 1 956
- Bibliographic source:
- Zeitschrift für Lebensmittel-Untersuchung und -Forschung, June 1956, Volume 103, Issue 6, pp 413-424, DOI: 10.1007/BF01683646
Materials and methods
- Principles of method if other than guideline:
- Method according to Kärber G, Naunyn-Schmiedebergs Arch. exper. Pathol. Pharmakol. 162, 480 (1931).
Rats were given different doses by gavage of undiluted 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' and observed for 7 days for clinical signs and mortality. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate
- EC Number:
- 905-983-8
- Molecular formula:
- C21H32O4; C22H42O4; C20H22O4
- IUPAC Name:
- Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMAL
- Weight at study initiation: 120-180 g
- Housing: single
- Diet ad libitum
- Water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): >20
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Rats wer given different doses by gavage of undiluted 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' and observed for 7 days for clinical signs and mortality.
Method according to Kärber G, Naunyn-Schmiedebergs Arch. exper. Pathol. Pharmakol. 162, 480 (1931). - Doses:
- no details given
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- Rats wer given different doses by gavage of undiluted 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' and observed for 7 days for clinical signs and mortality.
Method according to Kärber G, Naunyn-Schmiedebergs Arch. exper. Pathol. Pharmakol. 162, 480 (1931). - Statistics:
- calculation according to Burn JH, Biologische Auswertungsmethoden p. 29, Berlin: Springer 1937
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 10.4 mL/kg bw
- Remarks on result:
- other: 10400 mg/kg bw
- Mortality:
- no details given
- Clinical signs:
- other: somnolenz, staggering gait, diarrhea, poor general condition
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
10 rats per dose received different doses of undiluted 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' by gavage and were observed for 7 days for mortality and clinical finings. Animals showed staggering gait, somnolenz, suffered from diarrhea and poor general condition. The LD50 is 10.4 ml/kg bw accounting for 10400 mg/kg bw (density = 1).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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