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EC number: 204-130-0 | CAS number: 116-17-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-03-05 to 1994-07-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in compliance with international standard guidelines under GLP conditions. The study report was conclusive and well enough documented with all relevant information included.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Triisopropyl phosphite
- EC Number:
- 204-130-0
- EC Name:
- Triisopropyl phosphite
- Cas Number:
- 116-17-6
- Molecular formula:
- C9H21O3P
- IUPAC Name:
- tris(propan-2-yl) phosphite
- Test material form:
- other: clear liquid
- Details on test material:
- Lot #0-314-3033DR
Clear Liquid with density 0.93
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace animal
- Age at study initiation: 6 to 11 week
- Weight at study initiation: 201 to 293 g
- Fasting period before study: yes 16 to 20h prior dosing
- Housing: 5 per sex per cage (suspended wire mesh) Bedding was placed beneath the cagesand changed et least three time per week
- Diet (e.g. ad libitum): Fresh Purina Rodent Chow (Diet #5012)
- Water (e.g. ad libitum): Yes
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Controlled but no data on the range
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12 hour light darh cycle
IN-LIFE DATES: From:1994-05-11 to To: 1994-006-09
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- - No vehicle were used. Used as received and the dose was based on the sample weight as calculated from the specific gravity
- Doses:
- 1000 and 2000 mg/kg
- No. of animals per sex per dose:
- 5 per sex and dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Observation at 1h, 2h, 4h post dose and once weekly for toxicity and phramacological effects. Animals were observed twice weekly for mortality.
Weighing: Once pretest, weekly and at termination
- Necropsy of survivors performed: yes - Statistics:
- The LD 50 and 95% confidence limits were calculated if possible by the method Litchfield J.T Jr & F Wilcoxon JPET 96:99 1948 or Horn H. J. Biometrics 12:311 1956
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Mortality:
- No mortality at 1000 mg/kg
2 males death at 2000 mg/kg - Clinical signs:
- other: At 1000 mg/kg: Instances of theragy and ataxia ptosis and wetness of the anogenital area were noted on the day of dosing. All animals appeared normal from day 1 though day 14. At 2000 mg/kg: Two males died by day 4 with predeath physical signs of letharg
- Gross pathology:
- Necropsy results were normal on the survivals animals.
Abnormalities of the lungs, liver, testes, kidneys and gastrointestinal tract for the 2 death animals - Other findings:
- Wetness of the anogenital area and red staining of the nose and mouth area for the death anmals
Any other information on results incl. tables
Mortality table
Dose (mg/kg |
Treated |
Dead |
||
|
Male |
Female |
Male |
Female |
1000 |
5 |
5 |
0 |
0 |
2000 |
5 |
5 |
2 |
0 |
Body weight and dose volume
Dose |
Sex |
N° |
Dosing volume (mL) |
Body weight (g) |
||
D0 |
D7 |
D14 |
||||
1000 |
Male |
1 |
0.28 |
262 |
317 |
350 |
2 |
0.31 |
283 |
355 |
402 |
||
3 |
0.29 |
272 |
347 |
386 |
||
4 |
0.30 |
281 |
348 |
394 |
||
5 |
0.32 |
293 |
373 |
410 |
||
Mean |
278 |
348 |
388 |
|||
S.D. |
11.7 |
20.2 |
23.3 |
|||
N |
5 |
5 |
5 |
|||
Female |
6 |
0.24 |
220 |
267 |
282 |
|
7 |
0.24 |
222 |
256 |
266 |
||
8 |
0.26 |
239 |
281 |
308 |
||
9 |
0.22 |
207 |
244 |
265 |
||
10 |
0.23 |
211 |
251 |
259 |
||
Mean |
220 |
260 |
276 |
|||
S.D. |
12.4 |
14.5 |
19.8 |
|||
N |
5 |
5 |
5 |
|||
2000 |
Male |
11 |
0.45 |
211 (dead hour 4 (207g)) |
||
12 |
0.46 |
214 |
298 |
342 |
||
13 |
0.43 |
201 |
258 |
283 |
||
14 |
0.48 |
223 |
313 |
364 |
||
15 |
0.49 |
227 (Dead day 4 (193 g)) |
||||
Mean |
215 |
290 |
330 |
|||
S.D. |
10.3 |
28.4 |
41.9 |
|||
N |
5 |
3 |
3 |
|||
Female |
16 |
0.48 |
224 |
262 |
285 |
|
17 |
0.46 |
215 |
251 |
272 |
||
18 |
0.46 |
212 |
248 |
277 |
||
19 |
0.44 |
206 |
234 |
260 |
||
20 |
0.44 |
205 |
241 |
262 |
||
Mean |
212 |
247 |
271 |
|||
S.D. |
7.7 |
10.6 |
10.4 |
|||
N |
5 |
5 |
5 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD 50 is greater than 2000 mg/kg
- Executive summary:
The acute oral toxicity of Triisopropyl phosphite (TIPP) was assessed in a study on the rats according to the OECD Guideline 401 and in accordance with GLP.
The rats were given a single oral dose of test material at 1000 and 2000 mg/kg (5 animals per sex). The animals were observed for fourteen days after the day of dosing and were then killed for gross pathological examination.
No mortality was observed at 1000 mg/kg. Clinical signs were observed up to 4 hours after treatment. No further signs were observed until sacrifice at day 14. Nothing was noted during the gross pathological examination.
At 2000 mg/kg, 2 males died: One 4 hours after dosing and one on day 4. For the survival animals, only some clinical signs were observed just after dosing. Nothing was noted during the gross pathology examination.
Under these experimental conditions, the LD50 was determinated to be greater than 2000 mg/kg for the Triisopropyl phosphite (TIPP).
Therefore, no classification is required according to the regulation (EC) 1272/2008 (CLP) and the Directive 67/548/EEC criteria
This acute oral study is classified as acceptable. It satisfies the guideline requirement for an acute oral study in the rats
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