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Diss Factsheets
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EC number: 911-915-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
In a study according to OECD guideline 211 an overall NOEC of 83 µg/L and a LOEC of 180 µg/L was determined. The EC10 value for survival was estimated to be 81 µg/L, with a 95% confidence interval of 51 to 129 µg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 81 µg/L
Additional information
A flow-through life-cycle toxicity test with
Daphnia magna was performed according to OECD guideline 211. The
cladoceran, Daphnia magna, was exposed to Olaflur at the following
nominal concentrations 13, 25, 50, 100 and 200 µg/L corresponding to the
mean measured concentrations of 11, 18, 42, 83 and 180 µg/L under
flow-through conditions for 21 days. There were no statistically
significant treatment-related effects on reproduction or growth at
concentrations ≤180 µg/L in comparison to the negative control. Survival
was the most sensitive biological endpoint measured in the
study. Daphnids exposed to Olaflur at a mean measured concentration of
180 µg/L had a biologically meaningful reduction in survival in
comparison to the negative control.
Consequently, the overall NOEC for the study was determined to be 83
µg/L and the LOEC was determined to be 180 µg/L. The EC10 value for
survival was estimated to be 81 µg/L, with a 95% confidence interval of
51 to 129 µg/L, while the EC20 value was estimated to be 127 µg/L, with
a 95% confidence interval of 70 to 174 µg/L. The EC50 value for survival
was empirically estimated to be greater than the highest test
concentration, since there was less than a 50% decrease in survival in
any treatment group in comparison to the negative control. Since there
was less than 10% inhibition in any treatment for the reproduction and
growth endpoints in comparison to the negative control, the IC10 and
IC20 values were empirically estimated to be >180 µg/L, the highest
concentration tested.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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