Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-369-2 | CAS number: 81-68-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 April 2014 to 03 September 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Test material: FAT 36034/W
Batch no.: Q30450ADZX
Appearance/color: Solid/red - Radiolabelling:
- no
- Details on sampling:
- The test item solutions were prepared by adding 1 mL stock solution into an 100 mL volumetric flask and accurately filled up with the buffer solutions. Under argon atmosphere 2.0 mL of the test item solutions were given into several amber glass vials. The vials were closed with Teflon
sealed screw caps. At the sampling time the samples were diluted with 2.0 mL acetonitrile. The concentration did not exceed 0.01 M or the half saturation concentration. The determined effective concentrations prior to storage at 50 °C were 1.24 mg/L at pH 4, 1.29 mg/L at pH 7 and
1.34 mg/L at pH 9. - Buffers:
- The test was carried out at three different pH values: 4.0, 7.0 and 9.0. For this purpose, buffer solutions were prepared using reagent grade chemicals and deionized water. Applicable buffer systems are described in the Appendix of EC method C.7 (92/69/EC), OECD guideline 111. The citrate buffer pH 4, the phosphate buffer pH 7 and the borate buffer pH 9 were prepared in a concentration of 0.05 M on the basis of the undissociated acids. The pH value of the buffer solutions used during the test were determined with a calibrated pH meter at the selected temperature with a precision of 0.1 pH units.
- Details on test conditions:
- The test was carried out using a thermostatically controlled water bath at +/- 0.5 °C of the chosen temperature. The temperature was kept and measured to within +/- 0.1 °C. Photolytic interference was avoided. All suitable precautions were taken to exclude dissolved oxygen (bubbling the buffer with argon for five minutes before preparing the test solution).
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.24 mg/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.29 mg/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.34 mg/L
- Number of replicates:
- 4 at each pH-value
- Preliminary study:
- A preliminary test was performed at 50 +/- 0.5 °C at three pH values: 4.0, 7.0 and 9.0. A sufficient number of measurements were made, in order to
be able to estimate whether for each pH value and at 50 °C, the half-life time (t1/2) is less than 10 % of hydrolysis after 120 hours. These values
correspond to a half-life time higher than one year under conditions more representative of those of the environment (25 °C). - Transformation products:
- not measured
- % Recovery:
- 107
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 99.2
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 99.3
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- No significant changes of the content in the samples were observed. At pH 4, 7 and 9 less than 10 % of the test item were hydrolysed within 120 hours at 50 °C.
- Validity criteria fulfilled:
- yes
- Conclusions:
- FAT 36034/W was found to be hydrolytically stable.
- Executive summary:
The abiotic degradation of the test substance as a function of pH in aqueous solution was determined according to OECD guideline 111 and EC method C.7 (440/2008). A preliminary test was performed at 50 +/- 0.5 °C at three pH values: 4.0, 7.0 and 9.0. The degradation of FAT 36034/W was less than 10 % at pH 4, pH 7, pH 9 at 50 °C over a period of 120 hours. Therefore, the corresponding half-life time at 25 °C can be estimated to be longer than one year.
Reference
Table1: Time course of FAT 36034/W concentration at pH 4 at 50 °C
Time | Determined Content of FAT 36034/W in Sample | Actual concentration | |
[h] | [mg/L] | in % of initial conc. | |
0 | 1.24 | 100 | |
120 | 1.32 | 107 |
Table2: Time course of FAT 36034/W TE concentration at pH 7 at 50 °C
Time | Determined Content of FAT 36034/W in Sample | Actual concentration | |
[h] | [mg/L] | in % of initial conc. | |
0 | 1.29 | 100 | |
120 | 1.28 | 99.2 |
Table3: Time course of FAT 36034/W TE concentration at pH 9 at 50 °C
Time | Determined Content of FAT 36034/W in Sample | Actual concentration | |
[h] | [mg/L] | in % of initial conc. | |
0 | 1.34 | 100 | |
120 | 1.33 | 99.3 |
Description of key information
The abiotic degradation of the test substance as a function of pH in aqueous solution was determined according to OECD guideline 111 and EC method C.7 (440/2008). The degradation of FAT 36034/W was less than 10 % at pH 4, pH 7, pH 9 at 50 °C over a period of 120 hours. Therefore, the corresponding half-life time at 25 °C can be estimated to be longer than one year.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)