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Diss Factsheets
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EC number: 255-670-9 | CAS number: 42125-46-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Tert. butylchloroformate is corrosive to the skin. As the substance is corrosive to the skin, serious damages to the eye is implied.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
4 -tert.-butylcyclohexylchroformate is corrosive to skin in a study comparable to OECD 404. A cloth (1 x 1 cm) soaked with 4 -tert.-butylcyclohexylchroformate was applied onto the skin of two rabbits. After 4 h the test substance was washed away. Strong erythema described as large and in areas surrounding the application site and slight edema have been noted. Beyond this Full thickness necrosis as well as crust scars and scale formation have been observed. Effects were not fully reversible with in 8 days.
50 μl 4 -tert.-butylcyclohexylchroformate were instilled into the eyes of 2 vienna whit rabbits Effects observe were sored. Due to the maked erythema in both rabbits in the first 24 h and the questional reversable cornea demage (fluoresein staining) the test substance is irritating ore severly irritating to the eyes. These effects developed after application of only 50 µl instead of 100 µl as demanded by OECD 405. This may hae influenced reverability of cornea damage. As the substance is corrosive to the skin, serious damages to the eye is implied.Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: highly irritating
Justification for classification or non-classification
Tert butylchloroformate is corrosive according to the classification criteria laid down in EU Regulation 67/548 (R34) and EU Regulation 1272/2008 (skin irr/corr Cat 1b). This classification implies severe damage to the eyes (R41; eye irr/cor cat 1).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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