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EC number: 940-300-7 | CAS number: 1339119-15-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The ready biodegradation of the test substance, TM 11-213, was 0 % at 21°C after 28 days according to OECD Test Guideline 301B using the CO2 Evolution method. Before this test was carried out pre-study solubility work was performed in order to determine the most suitable method of preparation. From the pre-study solubility work and following the recommendations of the International Standards Organisation (ISO, 1995) it was concluded that the optmal dispersion was obtained when the test item was ultrasonicated in approximately 400 mL mineral media for 15 minutes prior to addition to the test vessel. The test item, at a concentration of 10 mg Carbon/L, was exposed to activated sewage sludge micro-organisms with mineral medium in sealed culture vessels in the dark at approximately 21°C for 28 days. The biodegradation of the test item was assessed by the determination of carbon dioxide produced. The test item attained 0 % biodegradation after 28 days and therefore cannot be considered to be readily biodegradable under the strict terms and conditions of OECD Guideline No. 301B. In the toxicity control (sodium benzoate plus test substance the biodegradation of the control exceeded the 25% limit which according to the test criteria confirmed that the test substance wasnot inhibitory to the sludge micro-organisms.. Value used for CSA: Biodegradation in water: under test conditions no biodegradation observed
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Two studies were performed to investigate the ready biodegradabilityof the test item in the presence of unacclimatized sewage sludge micro-organisms. In he first study no measurable biodegradation was observed. This result was somewhat unexpected because some biodegradation was anticipated based on BIOWIN 5 and 6 predictions, which showed a probability between 0.7 and 0.8. The computer models may have overpredicted since the fused rings are considered to be hindering biodegradation even though the alkyl side chain was expected to be biodegradable. The biodegradation may also be hindered because of limited water solubility which would decrease bioavailability to the sludge microorganisms. Therefore a second test was performed.
The first ready biodegradability study was performed according to OECD Test Guideline 301F - Manometric Respirometry Test method. Unacclimatised sewage microorganisms were used and the amount of oxygen consumed was measured over a28-day test period. The test item was adsorbed onto a glass fibre filter and then added to the inoculated medium in test vessel at a level of 33.2 mg/L, equivalent to 95.5 mg ThOD/L (n=2). The percentage degradation of TM 11-213 after 28 days averaged 0.5 % (n = 2).
In view of the anticipated difficulties associated with the evaluation of the biodegradability of organic compounds with low water solubility, a modification to the standard method of preparation of the test concentration was included in a second study assess the ready biodegradabilityof the test item in an aerobic system.. The method followed was compatible with the OECD Test Guideline 301B-CO2 Evolution test method, described at the key information.
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