Registration Dossier
Registration Dossier
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EC number: 807-059-9 | CAS number: 945558-97-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Remarks:
- other: human test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2011
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Human Repeat Insult Patch Test
- Principles of method if other than guideline:
- Reference: Appraisal of the Safety of Chemicals in Food, Drugs and Cosmetics published by The Association of Food and Drug Officials of The United States.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-[(3,4,5-trimethoxyphenyl)methylidene]pentane-2,4-dione
- EC Number:
- 807-059-9
- Cas Number:
- 945558-97-4
- Molecular formula:
- C15H18O5
- IUPAC Name:
- 3-[(3,4,5-trimethoxyphenyl)methylidene]pentane-2,4-dione
Constituent 1
In vitro test system
- Source species:
- human
- Amount/concentration applied:
- 0.2ml of 2% Synoxyl HSS in corn oil.
0.2ml of 5% Synoxyl HSS in Synovea DOI. - Number of replicates:
- 50
Results and discussion
In vitro
Results
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- The test material when tested under occlusive conditions at 2% dilution in corn oil and 5% dilution in Synovea DOI may be considered as a NON-PRIMARY IRRITANT to the skin according to the reference.
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