Registration Dossier
Registration Dossier
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EC number: 219-460-0 | CAS number: 2439-35-2
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Adequacy of study:
- other information
Data source
Reference
- Title:
- No information
- Author:
- Ministry of Environment, Japan(1997e): unpublished report on|Daphnia magna Reproduction Test (No.6B702G)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Version / remarks:
- Cited as OECD Guide-line 202, part 2 (Daphnia sp., Reproduction Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-(dimethylamino)ethyl acrylate
- EC Number:
- 219-460-0
- EC Name:
- 2-(dimethylamino)ethyl acrylate
- Cas Number:
- 2439-35-2
- Molecular formula:
- C7H13NO2
- IUPAC Name:
- 2-(dimethylamino)ethyl prop-2-enoate
- Details on test material:
- TS-Freetext:
SOURCE: Wako Pure Chemical Industries, LTD (Japan)
PURITY: 99.9%
IMPURITY/ADDITIVE/ETC.: not described
ANY OTHER INFORMATION: Lot No.SKK4558, got on Dec.25,1996
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 3 mg/L
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 10 mg/L
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 6.27 mg/L
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Effect conc.:
- 3.94 mg/L
Any other information on results incl. tables
RS-Freetext:
RESULTS: RANGE FINDING TEST: 48hr EiC50 = 9.92 mg/L
RESULTS: EXPOSED
- Nominal/measured concentrations: The concentration was
measured immediately after the preparation.
Nominal Measured concentration [mg/L] (%)
concentration Preparation
[mg/L] 1st 2nd
------------------- --------------- --------------
1000 826 (83%) 832 (83%)
----------------------------------------------------------
- Effect data:
21 day LC50 = 3.94 mg/L ( 95% c.l.: 3.26 - 4.84 mg/L)
21 day ErC50 = 6.27 mg/L ( 95% c.l.: 0.100 - 10.0 mg/L)
21 day NOECr = 3.00 mg/L
21 day LOECr = 10.0 mg/L
- cumulative reproduction:
(1) Cumulative number of dead parental Daphnia and
mortality during
exposure of 21day
Nominal Number of Mortality
concentration dead parental (%)
[mg/L] Daphnia
------------------ ------------- ---------------------
control 1 ( 3) at 20th day
0.100 1 ( 3) at 20th day
0.300 2 ( 5) at 21th day
1.00 4 ( 10) at 21th day
3.00 6 ( 15) at 20th day
10.0 40 (100) at 18th day
----------------------------------------------------------
(2) mean days required to first brood production during
exposure to 2-(dimethylamino)ethyl acrylate:
Nominal Mean days
concentration
[mg/L]
------------ ----------------
control 7.25
0.100 7.00
0.300 7.00
1.00 7.00
3.00 7.00
10.0 7.50
------------------------------------
(3) mean cumulative number of juveniles produced per adult
during exposure after 21 day
Nominal Number
concentration
[mg/L]
------------- -----------
control 138.1
0.100 131.8
0.300 80.2
1.00 134.0
3.00 149.4
10.0 13.1
--------------------------------
RESULTS: TEST WITH REFERENCE SUBSTANCE
- Results: K2Cr2O7 pure grade: 48 hr EiC50 = 0.23 mg/L
(immobility data)
STATISTICAL RESULTS:
Applicant's summary and conclusion
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