Registration Dossier
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EC number: 239-491-3 | CAS number: 15471-17-7
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Calculation with BCFBAFWIN v3.00 (EPIWIN software by US-EPA), Bioconcentration factor (BCF): 3.16 (regression-based estimate)
Key value for chemical safety assessment
- BCF (aquatic species):
- 3.16 L/kg ww
Additional information
The prediction for the Bioconcentration factor (BCF) of the test substance was determined by the computer program BCFBAFWIN v3.00 (EPIWIN software) by US-EPA (Chemservice S.A., 2011). Furthermore the whole body primary biotransformation rate estimation for fish was calculated with the notation that the bio half-life normalized to 10 g fish at 15 °C. It is possible to predict the apparent metabolism half-life in fish for three different trophic levels (lower, mid and upper).
In general, the Bioconcentration factor of a substance describes the accumulation potential of a substance dissolved in water by an aquatic organism. BCFBAF v3.01 calculates also the BAF (Bioaccumulation factor) of the chemical, which is defined as the steady-state (equilibrium) ratio of the substance concentration in an organism to the concentration in the surrounding medium. However, this value is not taken into account for the risk assessment and is not relevant for a registration under REACH Regulation (EC) 1907/2006.
Using the regression-based estimate (traditional method) a BCF of 3.16 L/kg wet-wt was calculated. Using the Arnot-Gobas method, which is based on mechanistic first principles, the BCF results in a value of 0.90 L/kg wet-wt. The whole body primary biotransformation rate estimate for fish gives a half-life of 0.12 days, whereby the rate constant (kM) for 10 g fish is designated as 5.79/day. This is taken into account to predict the apparent metabolism half-life in fish for the substance. For the lower trophic level a BCF of 0.95 L/kg wet-wt is calculated, whereas for the mid trophic level the BCF will result in 0.94 L/kg wet-wt and the higher trophic level gives a value of 0.90 L/kg wet-wt.
This procedure is scientifically accepted and considered as reliable with restrictions (Klimisch 2). Furthermore, it can be taken into account for the chemical safety assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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