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Diss Factsheets
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EC number: 425-430-1 | CAS number: 6746-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There only limited information available for the assessment of the skin sensitization potential of Ethynyl cyclopropane.
Skin sensitization
The substance Ethynyl cyclopropane was tested for its sensitizing effect on the skin of the guinea pig in the Maximization Test based on the EU method B.6 (skin sensitization), but unfortunately the whole study report is currently not available..
Ten animals in the test group and five animals in the test group were used. The induction phase was carried out with a 10 % dilution of the test material, both for intradermal and epicutaneous rout of induction. Slight signs of irritation and slight necrosis were observed after intradermal induction and slight erythema was observed after the epicutaneous induction procedure. After the challenge application, no cutaneous reactions were observed in the animals of the control group (0/5) at the 24-hour and the 48 hour reading as well as in the test group (0/10) for both readings at 24 and 48 h after the challenge. Further effects in response to the treatment procedure were not noted. Therefore, a sensitizing effect to the test article was not induced under the respective conditions of the test
Migrated from Short description of key information:
Skin
Guinea pig (OECD 406): sensitizing (Huntingdon Life Sciences Ltd)
Guinea pig (OECD 406): sensitizing (Huntingdon Life Sciences Ltd)
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
Respiratory tract
Actually, there is no information available.
Justification for classification or non-classification
Based on the test result of the Guinea Pig Maximization Test and applying the criteria of Annex VI/II D of the Council Directive of July 29, 1983 for the 5th Amendment of the Directive 67/548 EEC (= 83/467 EEC)) for test evaluation, the test substance does not fulfill the criteria of being a skin sensitizer and therefore need not to be classified according to EU or GHS criteria. There is no indication given that Ethynyl cyclopropane is a sensitizer of the respiratory tract.
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