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Diss Factsheets
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EC number: 946-945-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The concentration of the test substance was not stable during the test. The test item likely absorbed to the glass wall or the test organisms.
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- The test concentration was measured at 0, 24, 48 an 96 hours.
The fish were checked for mortality after 2, 24, 48, 72 and 96 hours. - Vehicle:
- yes
- Details on test solutions:
- 0, 10, 17.8, 31.6, 56.2 and 100 µg/L, applied dissolved in ethanol and water.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Juvenile fish of the same age and size have been used. They had been kept for 14 days under stable conditions.During the holding period, they were fed up to 48 hours before the test.
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- No
- Hardness:
- Reconstituted test water: analytical grade salts were dissolved to obtain water hardness of 2.5 mmol l-1.
- Test temperature:
- 21.7 - 23.2 °C
- pH:
- The pH ranged from 6-9 and varied not more than 0.4 units.
- Dissolved oxygen:
- The dissolved oxygen was ≥6.6 mg/L.
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal: 0, 10, 17.8, 31.6, 56.2 and 100 µg/L.
Measured: Levels could be detected only in 3 samples, presumably due to sorption of the test substance to the glass walls or to the test organisms. - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): open / closed
- Material, size, headspace, fill volume:
- Aeration:
- Type of flow-through (e.g. peristaltic or proportional diluter):
- Renewal rate of test solution (frequency/flow rate):
- No. of organisms per vessel:
- No. of vessels per concentration (replicates):
- No. of vessels per control (replicates):
- No. of vessels per vehicle control (replicates):
- Biomass loading rate:
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:
- Total organic carbon:
- Particulate matter:
- Metals:
- Pesticides:
- Chlorine:
- Alkalinity:
- Ca/mg ratio:
- Conductivity:
- Culture medium different from test medium:
- Intervals of water quality measurement:
OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod: 16 hours
- Light intensity:
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
TEST CONCENTRATIONS
- Spacing factor for test concentrations:
- Justification for using less concentrations than requested by guideline:
- Range finding study
- Test concentrations:
- Results used to determine the conditions for the definitive study: - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 10 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- EC10
- Effect conc.:
- ca. 31.6 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 55.9 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: not available
- Details on results:
- While lowest mortality was observed at the lowest dose, and highest mortality at the highest dose, there was no consistent dose-response relationship. The intermediate doses showed lower mortality than the low dose, as is reported in the table below under "Any other information on results incl. tables".
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- Reference is made to Appendix C of the study report.
- Sublethal observations / clinical signs:
Nominal test concentration [ug l-1]
No. of exposed fish
2h
24h
48h
72h
96h
0 (control)
7
0
0
0
0
0
0 (solvent control)
7
0
0
0
0
0
10
7
0
0
0
0
0
17.8
7
0
4
4
5
5
31.6
7
0
0
0
1*
2*
56.2
7
0
2
2
2*
3*
100
7
0
4
7
7
7
* All of the survivors showed signs of distress such as apathy and lateral swim and some were lying on one side
- Validity criteria fulfilled:
- yes
- Conclusions:
- Despite some deficiencies, the results are in line with other available data on d-Phenothrin.
EC0 = 10 µg/L
EC10 = 31.6 µg/L
LC50 = 55.9 µg/L - Executive summary:
EC0 = 10 µg/L
EC10 = 31.6 µg/L
LC50 = 55.9 µg/L
Reference
Description of key information
The acute aquatic toxicity to fish was found being 55.9 µg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 55.9 µg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.