Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-123-2 | CAS number: 1746-03-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: inherent biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Oktober 1992 - January 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 9888 Water quality - Evaluation of ultimate aerobic biodegradability of organic compounds in aqueous medium - Static test (Zahn-Wellens method)
- Version / remarks:
- 1991
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: 88/302/EWG (Teil C)
- Version / remarks:
- EG Amtsblatt L 133, 30.5.1988
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, industrial, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: sewage treatment plant of Höchst and Kelsterbach, ratio 1:1
- Pretreatment: no
- Concentration of sludge: 9.4 g dry substance /L
- Initial cell concentration: 70 mL sludge - Duration of test (contact time):
- > 0 - < 28 d
- Initial conc.:
- 192.6 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Composition of medium: as discribed in EEC-Directive, 1.6.1.4
- Additional substrate: no
- Test temperature: 21 + /- 2 °C
- pH: 7.4
- pH adjusted: yes, with NaOH
- Aeration: yes
- Suspended solids concentration: 70 mL sludge suspension
TEST SYSTEM
- Culturing apparatus: 3L beaker
- Number of culture flasks/concentration: 3
- Method used to create aerobic conditions: aeration
- Measuring equipment: pH-Meter Portamess, OXI-Meter 196
SAMPLING
- Sampling frequency: after 0, 1, 4, 7, 11, 15, 19, 27 and 28 days
- Sampling method: 15 mL for detection of DOC with
- Sample storage before analysis: no
- Pretreatment: Filtration with folded filters
CONTROL AND BLANK SYSTEM
- Inoculum blank: Inoculum and Reaction medium without test substance
- Toxicity control: Inoculum and Reaction medium with Diethylenglykol (DOC 220.5 mg/L)
- Reference substance:
- diethylene glycol
- Preliminary study:
- no preliminary study
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 9
- Sampling time:
- 28 d
- Details on results:
- The degradation of the test item had a maximum of 13 % on day 15 and day 19, with an end value of 9% after 28 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not inherently biodegradable
- Conclusions:
- The biodegradation of the test substance was 9% after 28 days. Therefore, the test substance is not inherently biodegradable in the Zahn-Wellens test.
- Executive summary:
In order to assess the biotic degradation, a inherent biodegradability test was performed which allows the biodegradability to be measured in an aerobic medium. The inherent biodegradability was determined in the Zahn-Wellens test according to OECD 302B and ISO 9888, and in compliance with the OECD principles of Good Laboratory Practice. In the biodegradability tests, sludge was inoculated into a chemically defined liquid medium containing the test substance as sole carbon and energy source. The test compound is exposed to the inoculum, consisting of relatively low numbers of microorganisms from an activated sludge plant, under aerobic conditions for a period of at least 28 days. The biodegradation of the test substance was 9% after 28 days. Hence, the test substance is not inherently biodegradable in the Zahn-Wellens test (28 days) and should therefore not be classified as readily biodegradable. The reference substance, Diethylenglykol, was degraded more than 75% after 14 days.
Reference
Description of key information
The biodegradation of the test substance was 9% after 28 days. Therefore, the test substance is not inherently biodegradable in the Zahn-Wellens test.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
In order to assess the biotic degradation, an inherent biodegradability test was performed which allows the biodegradability to be measured in an aerobic medium. The inherent biodegradability was determined in the Zahn-Wellens test according to OECD 302B and ISO 9888, and in compliance with the OECD principles of Good Laboratory Practice. In the biodegradability tests, sludge was inoculated into a chemically defined liquid medium containing the test substance as sole carbon and energy source. The test compound is exposed to the inoculum, consisting of relatively low numbers of microorganisms from an activated sludge plant, under aerobic conditions for a period of at least 28 days. The biodegradation of the test substance was 9% after 28 days. Hence, the test substance is not inherently biodegradable in the Zahn-Wellens test (28 days) and should therefore not be classified as readily biodegradable. The reference substance, Diethylenglykol, was degraded more than 75% after 14 days.
Two additional studies are available with very limited documentation, but supporting the above mentioned result (biodegradation < 10 % in 28 days).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.